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  • Functional PLGA NPs for oral drug delivery: recent strategies and developments.

Functional PLGA NPs for oral drug delivery: recent strategies and developments.

Mini reviews in medicinal chemistry (2012-09-15)
L Martin-Banderas, M Durán-Lobato, I Muñoz-Rubio, J Alvarez-Fuentes, M Fernández-Arevalo, M A Holgado
ABSTRACT

This article presents the potential of PLGA nanoparticles for the oral administration of drugs. Different strategies are used to improve oral absorption of these nanoparticles. These strategies are based on modification of nanoparticle surface properties. They can be achieved either by coating the nanoparticle surface with stabilizing hydrophilic bioadhesive polymers or surfactants, or by incorporating biodegradable copolymers containing a hydrophilic moiety. Some substances such as chitosan, vitamin E, methacrylates, lectins, lecithins, bile salts and RGD molecules are employed for this purpose. Of especial interest are nanoparticles production methods and, in order to improve oral bioavailability, the mechanism of each additive.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
NanoFabTx PEG-PLGA drug formulation screening kit, for synthesis of PEGylated nanoparticles
Sigma-Aldrich
NanoFabTx PLGA-nano, for synthesis of 100 and 200 nm particles