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Cytotoxic triterpenoids from the leaves of Microtropis fokienensis.

Journal of natural products (2006-11-28)
I-Hsiao Chen, Fang-Rong Chang, Chin-Chung Wu, Shu-Li Chen, Pei-Wen Hsieh, Hsin-Fu Yen, Ying-Chi Du, Yang-Chang Wu
ABSTRACT

Five new triterpenoids, microfokienoxanes A-D (1-4) and 3beta,28-dihydroxy-11alpha-methoxyurs-12-ene (5), were isolated and identified from the leaves of Microtropis fokienensis, along with nine known compounds. The structures of the new compounds were elucidated by spectroscopic methods. The compounds obtained in this investigation were evaluated against a small panel of human cancer cell lines for cytotoxicity. Only compounds 3 and 5 exhibited cytotoxicity (IC50 < or = 5 microg/mL) for one or more cell lines.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
(−)-Epicatechin, ≥98% (HPLC), from green tea
Sigma-Aldrich
Kaempferol, ≥90% (HPLC), powder
Sigma-Aldrich
(−)-Epicatechin, ≥90% (HPLC)
Supelco
(−)-Epicatechin, analytical standard
Sigma-Aldrich
Kaempferol, ≥97.0% (HPLC)