Skip to Content
MilliporeSigma
  • Carnoquinolines Target Copper Dyshomeostasis, Aberrant Protein-Protein Interactions, and Oxidative Stress.

Carnoquinolines Target Copper Dyshomeostasis, Aberrant Protein-Protein Interactions, and Oxidative Stress.

Chemistry (Weinheim an der Bergstrasse, Germany) (2020-07-07)
Francesco Bellia, Giuseppa Ida Grasso, Ikhlas Mohamed Mohamud Ahmed, Valentina Oliveri, Graziella Vecchio
ABSTRACT

Metal dysregulation, oxidative stress, protein modification, and aggregation are factors strictly interrelated and associated with neurodegenerative pathologies. As such, all of these aspects represent valid targets to counteract neurodegeneration and, therefore, the development of metal-binding compounds with other properties to combat multifactorial disorders is definitely on the rise. Herein, the synthesis and in-depth analysis of the first hybrids of carnosine and 8-hydroxyquinoline, carnoquinolines (CarHQs), which combine the properties of the dipeptide with those of 8-hydroxyquinoline, are reported. CarHQs and their copper complexes were characterized through several techniques, such as ESI-MS and NMR, UV/Vis, and circular dichroism spectroscopy. CarHQs can modulate self- and copper-induced amyloid-β aggregation. These hybrids combine the antioxidant activity of their parent compounds. Therefore, they can simultaneously scavenge free radicals and reactive carbonyl species, thanks to the phenolic group and imidazole ring. These results indicate that CarHQs are promising multifunctional candidates for neurodegenerative disorders and they are worthy of further studies.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Albumin from human serum, lyophilized powder, essentially fatty acid free
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
8-Hydroxy-2-quinolinecarboxylic acid, ≥98.0% (HPLC)
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
1 g
Only 5 left in stock
Details...
$125.00
5 g
1 Estimated to ship on February 19, 2025
$591.00