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  • Plasmid-mediated qnrB2 and carbapenemase gene bla(KPC-2) carried on the same plasmid in carbapenem-resistant ciprofloxacin-susceptible Enterobacter cloacae isolates.

Plasmid-mediated qnrB2 and carbapenemase gene bla(KPC-2) carried on the same plasmid in carbapenem-resistant ciprofloxacin-susceptible Enterobacter cloacae isolates.

Antimicrobial agents and chemotherapy (2008-06-04)
Inna Chmelnitsky, Shiri Navon-Venezia, Jacob Strahilevitz, Yehuda Carmeli
ABSTRACT

Fourteen out of 16 carbapenem-resistant quinolone-susceptible Enterobacter cloacae isolates were found to carry qnrB2 and bla(KPC-2) genes encoded on the same plasmid. One isolate also carried the aac(6')-Ib-cr gene. Coexistence of quinolone resistance determinants and bla(KPC-2) on the same plasmid in quinolone-susceptible E. cloacae isolates may have important clinical implications.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Levofloxacin, 98.0-102.0% anhydrous basis (HPLC)
Sigma-Aldrich
Nalidixic acid, ≥98%
Sigma-Aldrich
Ciprofloxacin, ≥98% (HPLC)