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Crown-capped imidacloprid: a novel design and insecticidal activity.

Bioorganic & medicinal chemistry letters (2009-05-05)
Shinzo Kagabu, Masaru Takagi, Ikuya Ohno, Tsuyoshi Mikawa, Toru Miyamoto
ABSTRACT

Imidacloprid (IMI) derivatives conjugated with benzo-15-crown-5 and benzo-18-crown-6 structures, applied for the first time to explore novel insecticidal molecule, elicited strong excitatory toxic signs to the house flies and stunningly exhibited three to five times higher insecticidal activity than that of the parent IMI, yet the two benzo-crown structures themselves had no effect.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
15-Crown-5, 98%
Sigma-Aldrich
Benzo-15-crown-5, 98%