- Synthesis and antibacterial evaluation of novel 8-fluoro Norfloxacin derivatives as potential probes for methicillin and vancomycin-resistant Staphylococcus aureus.
Synthesis and antibacterial evaluation of novel 8-fluoro Norfloxacin derivatives as potential probes for methicillin and vancomycin-resistant Staphylococcus aureus.
European journal of medicinal chemistry (2011-02-25)
Naresh Sunduru, Leena Gupta, Kuldeep Chauhan, Nripendra N Mishra, Praveen K Shukla, Prem M S Chauhan
PMID21345548
ABSTRACT
A series of novel 8-fluoro Norfloxacin derivatives and the hybrids of its piperazinyl derivatives incorporated with 1,3,5-triazine and pyrimidine were synthesized. All the above compounds were evaluated for their antibacterial activity against Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus and methicillin & vancomycin-resistant S. aureus. Among all, compounds having Morpholine, N-methyl/phenyl/benzyl/pyrimidinyl piperazines and n-butylamine substitution at C-7 position, have shown increased potency in comparison to norfloxacin and ciprofloxacin.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
α,α,α-Trifluorotoluene solution, NMR reference standard, 0.05% in benzene-d6 (99.6 atom % D), NMR tube size 3 mm × 8 in.
Sigma-Aldrich
α,α,α-Trifluorotoluene solution, NMR reference standard, 0.05% in benzene-d6 (99.6 atom % D)
Sigma-Aldrich
α,α,α-Trifluorotoluene solution, NMR reference standard, 0.05% in benzene-d6 (99.6 atom % D), NMR tube size 10 mm × 8 in.