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Synthesis and antimicrobial evaluation of new benzofuran derivatives.

European journal of medicinal chemistry (2011-05-17)
Xizhen Jiang, Wenlu Liu, Wei Zhang, Faqin Jiang, Zhe Gao, Hao Zhuang, Lei Fu
ABSTRACT

Thirteen compounds, based on benzofuran skeleton bearing aryl substituents at its C-3 position through methanone linker, were synthesized and screened for their antibacterial and antifungal activities against four bacteria Escherichia coli, Staphylococcus aureus, Methicillin-resistant S.aureus, Bacillus subtilis, and a fungus Candida albicans. Four hydrophobic benzofuran analogs were found to exhibit favorable antibacterial activities (MIC(80) = 0.39-3.12 μg/mL), which were better than the control drugs.

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