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Effects of lysine analogs on Penicillium chrysogenum.

Applied and environmental microbiology (1977-12-01)
C G Friedrich, A L Demain
PMID413481
ABSTRACT

Compounds structurally related to lysine were tested against Penicillium chrysogenum Wis. 54-1255 for inhibition of growth, sporulation, and penicillin formation. This strain is relatively resistant to lysine analogs. The compounds that were the more active inhibitors of growth and whose activities were reversed by L-lysine were diaminohexynoic acid, N-epsilon-methyllysine, N-alpha-methyllysine, and diaminopimelic acid. These four compounds also inhibited sporulation, which was more sensitive to inhibition than growth was. Analogs strongly inhibiting benzyl-penicillin formation by resting mycelia were diaminohexynoic acid and N-epsilon-methyllysine. The action of the most active analog (diaminohexynoic acid) on penicillin synthesis was reversed by DL-alpha-aminoadipic acid.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Nα-Methyl-L-lysine monohydrochloride, ≥98.0% (TLC)
Sigma-Aldrich
Nε-Methyl-L-lysine hydrochloride, ≥98.0% (TLC)