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  • SF2446, new benzo[a]naphthacene quinone antibiotics. II. The structural elucidation.

SF2446, new benzo[a]naphthacene quinone antibiotics. II. The structural elucidation.

The Journal of antibiotics (1988-04-01)
S Gomi, T Sasaki, J Itoh, M Sezaki
ABSTRACT

Structures of new antibiotics SF2446A1, A2, A3, B1, B2 and B3 have been deduced by means of spectral analyses and chemical studies. The structure of SF2446A1 which is a main product of fermentation and has the strongest antimicrobial activity, has been proposed to be 11-(2,4-di-O-methyl-beta-L-rhamnopyranosyl)amino-5,6,6a,14a-tetrah ydro- 1,6,8,14a-tetrahydroxy-6a-methoxy-2-methoxycarbonyl-3-methyl- benzo[a]naphthacene-7,9,12,14-tetra-one. All of antibiotics have a novel benzo[a]naphthacene quinone skeleton and SF2446A1, A2, B1 and B2 have an N-glycosidic linkage with 2,4-di-O-methyl-L-rhamnose.

MATERIALS
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Brand
Product Description

Sigma-Aldrich
Sulfur dioxide solution, 2.0 M in acetonitrile