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IgM memory B cells: a mouse/human paradox.

Cellular and molecular life sciences : CMLS (2012-04-07)
Claude-Agnès Reynaud, Marc Descatoire, Ismail Dogan, François Huetz, Sandra Weller, Jean-Claude Weill
ABSTRACT

Humoral memory is maintained by two types of persistent cells, memory B cells and plasma cells, which have different phenotypes and functions. Long-lived plasma cells can survive for a lifespan within a complex niche in the bone marrow and provide continuous protective serum antibody levels. Memory B cells reside in secondary lymphoid organs, where they can be rapidly mobilized upon a new antigenic encounter. Surface IgG has long been taken as a surrogate marker for memory in the mouse. Recently, however, we have brought evidence for a long-lived IgM memory B cell population in the mouse, while we have also argued that, in humans, these same cells are not classical memory B cells but marginal zone (MZ) B cells which, as opposed to their mouse MZ counterpart, recirculate and carry a mutated B cell receptor. In this review, we will discuss these apparently paradoxical results.

MATERIALS
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Sigma-Aldrich
IgM Isotype Control from murine myeloma, clone MOPC 104E, 200 μg/mL, buffered aqueous solution, purified immunoglobulin