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  • Angle-resolved optical coherence tomography with sequential angular selectivity for speckle reduction.

Angle-resolved optical coherence tomography with sequential angular selectivity for speckle reduction.

Optics express (2007-05-14)
A E Desjardins, B J Vakoc, W Y Oh, S M Motaghiannezam, G J Tearney, B E Bouma
ABSTRACT

We present a novel method for rapidly acquiring optical coherence tomography (OCT) images at multiple backscattering angles. By angularly compounding these images, high levels of speckle reduction were achieved. Signal-to-noise ratio (SNR) improvements of 3.4 dB were obtained from a homogeneous tissue phantom, which was in good agreement with the predictions of a statistical model of speckle that incorporated the optical parameters of the imaging system. In addition, the fast acquisition rate of the system (10 kHz A-line repetition rate) allowed angular compounding to be performed in vivo without significant motion artifacts. Speckle-reduced OCT images of human dermis show greatly improved delineation of tissue microstructure.

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Sigma-Aldrich
Titanium(IV) oxide, mixture of rutile and anatase, nanopowder, <100 nm particle size (BET), 99.5% trace metals basis