Synthesis of 7-chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines as antimicrobial agents.

Synthesis of 7-chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines as antimicrobial agents.

Bioorganic & medicinal chemistry (2006-05-03)

Bhawani Singh Rathore, M Kumar

ABSTRACT

7-Chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines have been synthesized by 2-amino-5-fluoro/5-trifluoromethyl/5-chloro-3-trifluoromethyl benzenethiols condensed with beta-diketone/beta-ketoesters in the presence of DMSO involving oxidative cyclization. Pharmacological activities have also been included.

MATERIALS

Product Number

Brand

Product Description

547948

Sigma-Aldrich

α,α,α-Trifluorotoluene, anhydrous, ≥99%

T63703

Sigma-Aldrich

α,α,α-Trifluorotoluene, ≥99%

733806

Sigma-Aldrich

α,α,α-Trifluorotoluene solution, NMR reference standard, 0.05% in benzene-d₆ (99.6 atom % D), NMR tube size 10 mm × 8 in.

551406

Sigma-Aldrich

α,α,α-Trifluorotoluene solution, NMR reference standard, 0.05% in benzene-d₆ (99.6 atom % D)

612685

Sigma-Aldrich

α,α,α-Trifluorotoluene solution, NMR reference standard, 0.05% in benzene-d₆ (99.6 atom % D), NMR tube size 3 mm × 8 in.