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  • A phase II study of weekly paclitaxel and doxifluridine combination chemotherapy for advanced/recurrent gastric cancer.

A phase II study of weekly paclitaxel and doxifluridine combination chemotherapy for advanced/recurrent gastric cancer.

Anticancer research (2011-01-29)
Izumi Takeyoshi, Fujio Makita, Yoshifumi Tanahashi, Shigeru Iwazaki, Tetsushi Ogawa, Naoki Tomizawa, Seiji Nakamura, Hitoshi Ishikawa, Toshihiro Ohya, Shinichi Kakinuma, Katsunao Nakagami, Yoshihiro Sato, Tetsuya Koyano, Takashi Roppongi, Masaru Izumi, Junya Kobayashi, Susumu Kawate, Yutaka Sunose, Mitsunobu Kobayashi, Tatsuya Yamada, Ichiro Sakamoto
ABSTRACT

Paclitaxel and doxifluridine (5'-DFUR) have distinct mechanisms of action and toxicity profiles. This study evaluated the antitumor activity and toxicities of combination chemotherapy with these drugs in patients with advanced/recurrent gastric cancer (AGC). Patients with histologically confirmed AGC, which was either unresectable or metastatic, were included in this study. The treatment consisted of 80 mg/m² paclitaxel given i.v. on days 1, 8, and 15 every 4 weeks, and 533 mg/m² doxifluridine given orally on days 1-5 every week. One hundred and four patients were evaluated for toxicity and 93 patients were evaluated for a therapeutic response. The overall response rate was 33.3% (1st line: 41.7%, 2nd line: 25.0%), including a complete remission in two patients, a partial remission in 29, stable disease in 39, progressive disease in 17; the response was not evaluable in six patients. The median overall survival was 287 days. Commonly observed grade 3/4 adverse events were leukopenia (13.5%), anorexia (3.8%), fatigue (3.8%) and diarrhea (2.9%). Paclitaxel and doxifluridine combination chemotherapy is a well-tolerated and convenient treatment regimen that can be given on an outpatient basis with promising efficacy for AGC.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
5-Fluoro-5′-deoxyuridine
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100 μg
Estimated to ship on March 21, 2025
$457.00