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Immunosuppressive decalin derivatives from red yeast rice.

Journal of natural products (2012-03-08)
Lin Zhu, Jing-Guang Lu, Ting Li, Guo-Yuan Zhu, Quan-Bin Han, Wen-Luan Hsiao, Liang Liu, Zhi-Hong Jiang
ABSTRACT

Five new decalin derivatives (1-5), together with two known compounds (6 and 7), were isolated from the ethyl acetate extract of red yeast rice. Their structures were elucidated by means of NMR and mass spectroscopic analyses. Monascusic lactone A (1) is the first reported naturally occurring decalin derivative possessing a spiro lactone at the C-1 position. The immunosuppressive effects of all these isolates (1-7) on human T cell proliferation were investigated, and all, especially monascusic acids B (2), C (3), D (4), and A (6) and heptaketide (7), suppressed human T cell proliferation in a dose-dependent manner from 10 to 100 μM. This is the first report on the immunosuppressive activity of decalin derivatives.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
cis-Decahydronaphthalene, 99%
Sigma-Aldrich
trans-Decahydronaphthalene, 99%
Sigma-Aldrich
Decahydronaphthalene, mixture of cis + trans, anhydrous, ≥99%
Sigma-Aldrich
Decahydronaphthalene, mixture of cis + trans, reagent grade, 98%