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  • Ketosulfonyl indoles in the regiodefined synthesis of tryptophols and related indole derivatives.

Ketosulfonyl indoles in the regiodefined synthesis of tryptophols and related indole derivatives.

Organic & biomolecular chemistry (2012-03-22)
Alessandro Palmieri, Marino Petrini
ABSTRACT

Reduction of ketosulfonyl indoles with sodium borohydride provides a ready entry to tryptophols in a regiocomplementary fashion with respect to the traditional oxirane ring-opening by indoles under Friedel-Crafts conditions. Compared to traditional β-ketosulfones, ketosulfonyl indoles show a peculiar behavior since they undergo a Lewis acid promoted elimination of the arylsulfonyl group allowing the preparation of indolyl-substituted 1,4-dicarbonyl derivatives.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
3-(2-Hydroxyethyl)indole, 97%