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  • Evaluation of antioxidant and immunity function of tetramethylpyrazine phosphate tablets in vivo.

Evaluation of antioxidant and immunity function of tetramethylpyrazine phosphate tablets in vivo.

Molecules (Basel, Switzerland) (2012-05-10)
Ling Guo, Aihong Wang, Yongle Sun, Chongen Xu
ABSTRACT

The aim of the study was to determine the effect of tetramethylpyrazine phosphate tablets (TPT), a Chinese medicine used for cardiovascular disease, on immunity activity and oxidative injury in rats. Heart failure (HF) was induced by isoproterenol (ISO). After the animal model was established, the rats were administered the TPT by gavage (once a day). The results indicated that TPT improved left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), ±dP/dt, heart weight/body weight. TPT could decrease the levels of tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6). Furthermore, it also could raise the activities of catalase, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), but reduce malonyldialdehyde (MDA) level. The results indicated that TPT improved cardiac function and myocardial fibrosis from myocardial injury, and this cardioprotection might be attributed to a reduction of oxidative stress and regulation of inflammation mediators.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2,3,5,6-Tetramethylpyrazine, 98%
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50 mg
Estimated to ship on June 15, 2025
from MILWAUKEE
$297.00
100 mg
Estimated to ship on June 15, 2025
from MILWAUKEE
$508.00
250 mg
Estimated to ship on June 15, 2025
from MILWAUKEE
$896.00
500 mg
Estimated to ship on January 28, 2025
from MILWAUKEE
$1,580.00
$1,374.60
1 g
In Stock
Details...
$2,730.00
Sigma-Aldrich
2,3,5,6-Tetramethylpyrazine, ≥98%, FG
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mg
Estimated to ship on June 15, 2025
from MILWAUKEE
$297.00
100 mg
Estimated to ship on June 15, 2025
from MILWAUKEE
$508.00
250 mg
Estimated to ship on June 15, 2025
from MILWAUKEE
$896.00
500 mg
Estimated to ship on January 28, 2025
from MILWAUKEE
$1,580.00
$1,374.60
1 g
In Stock
Details...
$2,730.00
Sigma-Aldrich
2,3,5,6-Tetramethylpyrazine, natural, ≥98%, FG
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SKUPack SizeAvailabilityPriceQuantity
50 mg
Estimated to ship on June 15, 2025
from MILWAUKEE
$297.00
100 mg
Estimated to ship on June 15, 2025
from MILWAUKEE
$508.00
250 mg
Estimated to ship on June 15, 2025
from MILWAUKEE
$896.00
500 mg
Estimated to ship on January 28, 2025
from MILWAUKEE
$1,580.00
$1,374.60
1 g
In Stock
Details...
$2,730.00
Supelco
2,3,5,6-Tetramethylpyrazine, analytical standard
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SKUPack SizeAvailabilityPriceQuantity
50 mg
Estimated to ship on June 15, 2025
from MILWAUKEE
$297.00
100 mg
Estimated to ship on June 15, 2025
from MILWAUKEE
$508.00
250 mg
Estimated to ship on June 15, 2025
from MILWAUKEE
$896.00
500 mg
Estimated to ship on January 28, 2025
from MILWAUKEE
$1,580.00
$1,374.60
1 g
In Stock
Details...
$2,730.00