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  • In vitro analysis of polymer candidates for the development of absorbable vascular filters.

In vitro analysis of polymer candidates for the development of absorbable vascular filters.

Journal of vascular and interventional radiology : JVIR (2012-07-31)
Mitchell D Eggers, Charles A Reitman
ABSTRACT

To test absorbable materials as a prelude to development of an absorbable vena cava filter for the prevention of pulmonary embolism (PE). Three absorbing polymer candidates, poliglecaprone (Monocryl; sizes 4-0 and 1), polyglactin (Vicryl; sizes 4-0 and 1), and polydioxanone (PDSII; sizes 4-0, 2-0, 0, and 1), were fabricated into vascular filters and evaluated in an engineered closed circulation system that replicated human physiologic characteristics. Material performance was determined over a period of 10 weeks via weekly tensile testing, yielding stress-versus-strain parameters. Control samples of the same absorbable polymers were also tested in a static buffer. PDSII (size 2-0) retained 69% strength in circulation versus 86% in control at 6 weeks (P < .0001) and 11% strength in circulation versus 51% in control at 10 weeks (P < .001). It was fully absorbed in circulation by 22 weeks. In contrast, Monocryl and Vicryl absorbed much faster, with Monocryl possessing 6% strength at 2 weeks in circulation and Vicryl reaching 0% strength at 4 weeks. Polydioxanone appears to be a strong candidate for novel absorbable vascular filters for PE prevention, with sufficient strength retention to catch emboli for at least 6 weeks and sequentially absorb via hydrolysis into CO(2) and H(2)O within 22 weeks.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Resomer® X 206 S, poly(dioxanone)