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  • Antihyperglycemic effect of syringaldehyde in streptozotocin-induced diabetic rats.

Antihyperglycemic effect of syringaldehyde in streptozotocin-induced diabetic rats.

Journal of natural products (2012-08-14)
Chia-Hsin Huang, Mei-Fen Chen, Hsien-Hui Chung, Juei-Tang Cheng
ABSTRACT

The antihyperglycemic effect of syringaldehyde (1), purified from the stems of Hibiscus taiwanensis, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats) showing type-1 like diabetes mellitus. Bolus intravenous injection of 1 showed antihyperglycemic activity in a dose-dependent manner in STZ-diabetic rats. An effective dose of 7.2 mg/kg of 1 attenuated significantly the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. A glucose uptake test showed that 1 exhibits an increase of glucose uptake activity in a concentration-related manner. Moreover, an effect by 1 was shown for insulin sensitivity in STZ-diabetic rats. The compound was found to increase insulin sensitivity in STZ-diabetic rats. These results suggest that syringaldehyde (1) can increase glucose utilization and insulin sensitivity to lower plasma glucose in diabetic rats.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Syringaldehyde, 98%
Sigma-Aldrich
Syringaldehyde, ≥98%, FG