- Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides Mat Salleh.
Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides Mat Salleh.
Molecules (Basel, Switzerland) (2013-01-25)
Rosalind Pei Theng Kim, Vicky Bihud, Khalit Bin Mohamad, Kok Hoong Leong, Jamaludin Bin Mohamad, Fasihuddin Bin Ahmad, Hazrina Hazni, Noraini Kasim, Siti Nadiah Abdul Halim, Khalijah Awang
PMID23344192
ABSTRACT
Eleven compounds:goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC(50)value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC(50) of 0.207 µM.