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  • The association between some endocrine disruptors in human plasma and the occurrence of congenital hypothyroidism.

The association between some endocrine disruptors in human plasma and the occurrence of congenital hypothyroidism.

Environmental toxicology and pharmacology (2013-02-05)
Hyunju Jung, Yonghee Hong, Donghwan Lee, Kijung Pang, Yunje Kim
ABSTRACT

Congenital hypothyroidism is a common pediatric endocrine disease. Endocrine disruptors are indicated as a possible cause of congenital hypothyroidism. We investigated the associations between endocrine disruptors and the occurrence of congenital hypothyroidism and passage of target compounds from the mother. The levels of phthalates (DEHP, MEHP, DBP, MBP and PA), alkylphenols (n-NP and t-OP), bisphenol, and isoflavones (equol, daidzein and genistein) were determined by gas chromatography-mass spectrometry (GC-MS) in infants. t-OP and PA concentrations in the patient group were significantly higher than in normal infants. Genistein concentrations in normal infants were significantly higher than in patients. We compared the plasma levels of target compounds in infants with their mothers. There was no correlation with the passage of endocrine disruptors and isoflavones from the mothers, except for t-OP, which was weakly correlated between mother and infant.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Dioctyl phthalate, ≥99.5%
Supelco
Bis(2-ethylhexyl) phthalate, Selectophore
Supelco
Bis(2-ethylhexyl) phthalate, PESTANAL®, analytical standard
Supelco
Bis(2-ethylhexyl) phthalate, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
Sigma-Aldrich
4-tert-Octylphenol, 97%
Supelco
Bis(2-ethylhexyl) phthalate solution, certified reference material, 2000 μg/mL in methanol
Supelco
4-tert-Octylphenol, analytical standard
Supelco
4-tert-Octylphenol solution, 1000 μg/mL in acetone, analytical standard