Skip to Content
MilliporeSigma
  • NIR imaging spectroscopy for quantification of constituents in polymers thin films loaded with paracetamol.

NIR imaging spectroscopy for quantification of constituents in polymers thin films loaded with paracetamol.

Analytica chimica acta (2013-02-16)
Guilherme L Alexandrino, Ronei J Poppi
ABSTRACT

Thin films loaded with the drug paracetamol were produced from polymer blends formed by hydroxypropylmethylcellulose (HPMC), polyvinylpyrrolidone (PVP) and polyethyleneglycol (PEG), at various mass ratios of polymers and drug defined by a D-optimal experimental design. NIR hyperspectral images were obtained from each thin film formulation and the pixel-to-pixel quantification of the constituents were carried out by partial least square (PLS) and multivariate curve resolution-alternating least square (MCR-ALS) with three different calibration/validation strategies. These strategies differ in the way to construct the calibration and validation matrices and they had to be carried out to suppress the bias on the quantification of the constituents in the polymer blend. The errors of prediction in the models from MCR-ALS were influenced by the calibration/validation strategy employed, but they were similar to the ones from PLS model. Concentration distribution maps were built after pixel-to-pixel predictions and their characteristics were analyzed.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Methyl cellulose, 27.5-31.5% methoxyl basis
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Methyl cellulose, tested according to Ph. Eur.
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Methyl cellulose, medium viscosity, Methoxyl content 27.5-31.5 %
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Povidone, meets USP testing specifications
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Methyl cellulose, viscosity: 4,000 cP
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Methyl cellulose, viscosity: 15 cP, BioReagent, suitable for cell culture
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Methyl cellulose, 26.0-33.0% (Methoxy group (dry basis)), meets USP testing specifications, viscosity: 1,500 cP
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Methyl cellulose, meets USP testing specifications, 26.0-33.0% (methoxyl group, on Dry Basis), viscosity: 400 cP
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Methyl cellulose, viscosity: 25 cP
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Methyl cellulose, viscosity: 1,500 cP
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Methyl cellulose, 27.5-31.5% (Methoxyl content), viscosity: 400 cP
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Kollidon® 25
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Methyl cellulose, viscosity: 15 cP
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Povidone, European Pharmacopoeia (EP) Reference Standard
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Supelco
Povidone, Pharmaceutical Secondary Standard; Certified Reference Material
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Methyl cellulose, viscosity 3000-5500 mPa.s, 2 % in H2O(20 °C)
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
(Hydroxypropyl)methyl cellulose, average Mn ~86,000
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
(Hydroxypropyl)methyl cellulose, viscosity 2,600-5,600 cP, 2 % in H2O(20 °C)(lit.)
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
(Hydroxypropyl)methyl cellulose, viscosity 40-60 cP, 2 % in H2O(20 °C)(lit.)
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
(Hydroxypropyl)methyl cellulose, average Mn ~10,000
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
(Hydroxypropyl)methyl cellulose, average Mn ~120,000
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
(Hydroxypropyl)methyl cellulose, average Mn ~90,000
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
(Hydroxypropyl)methyl cellulose, viscosity 80-120 cP, 2 % in H2O(20 °C)(lit.)
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
(Hydroxypropyl)methyl cellulose
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Hypromellose, meets USP testing specifications
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Polyvinylpyrrolidone, for molecular biology, nucleic acid hybridization tested, mol wt 360,000
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Polyvinylpyrrolidone, mol wt (number average molecular weight Mn 360kDa)
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Polyvinylpyrrolidone, powder, BioXtra, suitable for mouse embryo cell culture
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Polyvinylpyrrolidone, average mol wt 10,000
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00
Sigma-Aldrich
Polyvinylpyrrolidone, suitable for plant cell culture, average mol wt 10,000
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
50 mL
In Stock
Details...
$125.00