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  • Vacuum/compression valving (VCV) using parrafin-wax on a centrifugal microfluidic CD platform.

Vacuum/compression valving (VCV) using parrafin-wax on a centrifugal microfluidic CD platform.

PloS one (2013-03-19)
Wisam Al-Faqheri, Fatimah Ibrahim, Tzer Hwai Gilbert Thio, Jacob Moebius, Karunan Joseph, Hamzah Arof, Marc Madou
ABSTRACT

This paper introduces novel vacuum/compression valves (VCVs) utilizing paraffin wax. A VCV is implemented by sealing the venting channel/hole with wax plugs (for normally-closed valve), or to be sealed by wax (for normally-open valve), and is activated by localized heating on the CD surface. We demonstrate that the VCV provides the advantages of avoiding unnecessary heating of the sample/reagents in the diagnostic process, allowing for vacuum sealing of the CD, and clear separation of the paraffin wax from the sample/reagents in the microfluidic process. As a proof of concept, the microfluidic processes of liquid flow switching and liquid metering is demonstrated with the VCV. Results show that the VCV lowers the required spinning frequency to perform the microfluidic processes with high accuracy and ease of control.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Paraffin wax, SAJ first grade, mp 58-60 °C
Sigma-Aldrich
Paraffin wax, SAJ first grade, mp 56-58 °C
Sigma-Aldrich
Paraffin wax, SAJ first grade, mp 50-52 °C
Sigma-Aldrich
Paraffin wax, SAJ first grade, mp 52-54 °C
Sigma-Aldrich
Paraffin wax, SAJ first grade, mp 62-64 °C
Sigma-Aldrich
Paraffin wax, SAJ first grade, mp 40-42 °C
Sigma-Aldrich
Paraffin wax, mp ≥65 °C (ASTM D 87)
Sigma-Aldrich
Paraffin wax, mp 58-62 °C (ASTM D 87)
Sigma-Aldrich
Paraffin wax, tested according to Ph. Eur., low viscosity
Sigma-Aldrich
Paraffin wax, chunks (large), white
Sigma-Aldrich
Paraffin wax, mp 53-58 °C (ASTM D 87)
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Paraffin wax, pellets, white, tested according to Ph. Eur.
Sigma-Aldrich
Paraffin wax, tested according to Ph. Eur., high viscosity
Sigma-Aldrich
Paraffin wax, meets analytical specification of Ph. Eur., pastilles, white
Sigma-Aldrich
Paraffin wax, pellets, white
Sigma-Aldrich
Paraffin wax, SAJ first grade, mp 60-62 °C
Sigma-Aldrich
Paraffin wax, SAJ first grade, mp 64-66 °C