Supramolecular hydrogel based on graphene oxides for controlled release system.

Supramolecular hydrogel drug delivery system that composed of F127 modified small-sized graphene oxide (F127-SGO) and alpha-CD was prepared and the controlled release behavior was studied using doxorubicin hydrochloride (DOX) as a model drug. As compared with native hydrogel formed from F127 and alpha-CD, the SGO-containing hybrid hydrogel system shows multiple binding sites to load drug molecules and a more controllable release process that facilitates to tune the drug delivery system. These properties make the supramolecular hydrogel a potential candidate for controlled drug delivery system.