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  • [Effect of isatin and its derivatives on some indicators of carbohydrate metabolism].

[Effect of isatin and its derivatives on some indicators of carbohydrate metabolism].

Voprosy meditsinskoi khimii (1984-09-01)
V N Garalene, L I Mazhilis
ABSTRACT

Effect of isatin and of three its derivatives on content of lactate, pyruvate and glycogen was studied in rat tissues. The substances studied, except of 5-butylisatin, decreased the content of lactic acid with simultaneous increase of glycogen content in liver tissue under normal conditions. The pyruvate content was most markedly altered in presence of 5-bromoisatin and 5-butylisatin. In deficiency of oxygen a distinct increase in content of lactate and pyruvate was noted in animal tissues after the 5-bromoisatin preadministration. Under conditions of oxygen deficiency the substances studied were of distinct significance for more economical utilization of glycogen in liver tissue and skeletal muscles.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
5-Bromoisatin, technical grade, 90%