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  • Cation complexed DNA. A novel class of immunoadsorbents for anti-DNA antibodies.

Cation complexed DNA. A novel class of immunoadsorbents for anti-DNA antibodies.

Journal of immunological methods (1981-01-01)
V A DeBari, M A Needle
ABSTRACT

DNA can be precipitated as complexes with metal and organic cations. We have prepared these products using divalent metal cations (Cu2+, Mn2+, Ni2+, Zn2+, and Co2+) and ditetrazolium ions (blue tetrazolium and neotetrazolium). They are effective adsorbents, in vitro, for anti-nDNA antibodies and in reducing the titer of antinuclear antibodies in the sera from patients with autoimmune disease. They selectively adsorb most of the antinuclear components from a mixture of antimitochondrial and antinuclear antibodies.

MATERIALS
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Product Description

Sigma-Aldrich
Tetrazolium Blue Chloride, indicator for germination, suitable for microbiology, ≥90% (T)