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  • Novel coatings for stir bar sorptive extraction to determine pharmaceuticals and personal care products in environmental waters by liquid chromatography and tandem mass spectrometry.

Novel coatings for stir bar sorptive extraction to determine pharmaceuticals and personal care products in environmental waters by liquid chromatography and tandem mass spectrometry.

Analytica chimica acta (2013-04-10)
Núria Gilart, Núria Miralles, Rosa Maria Marcé, Francesc Borrull, Núria Fontanals
ABSTRACT

Two new commercially available polar coatings for stir bar sorptive extraction (SBSE), consisting of polyacrylate (PA) with a proportion of polyethyleneglycol (PEG) (Acrylate Twister(®)) and PEG modified silicone (EG Silicone Twister(®)), were evaluated and compared with the classic coating based on polydimethylsiloxane (PDMS Twister(®)) for the extraction of a group of pharmaceuticals and personal care products (PPCPs) from wastewater samples. The SBSE parameters, such as sample pH, agitation speed, extraction temperature, extraction time, desorption solvent and time, were optimised in order to achieve suitable sorption of the target analytes. The EG Silicone coating enabled more efficient extraction of some polar compounds as well as improving the sorption of apolar compounds, in comparison with the other two coatings. Finally, the method of SBSE followed by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) using the EG Silicone coating was validated achieving good linearity (r(2)>0.994, except for CBZ (r(2)>0.989)), precision (%RSD<17%) and low limits of quantification (LOQs) (20-40 ng L(-1)). The SBSE/LC-MS/MS methodology was applied for the determination of PPCPs in wastewater samples.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Poly(acrylic acid, sodium salt) solution, average Mw ~8,000, 45 wt. % in H2O
Sigma-Aldrich
Poly(acrylic acid, sodium salt) solution, average Mw ~1,200, 45 wt. % in H2O
Supelco
Poly(acrylic acid sodium salt), analytical standard, for GPC, 16,000
Sigma-Aldrich
Poly(acrylic acid sodium salt), average Mw ~2,100
Sigma-Aldrich
Poly(acrylic acid sodium salt), average Mw ~5,100 by GPC, powder