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  • Prolonged exposure to low levels of aluminum leads to changes associated with brain aging and neurodegeneration.

Prolonged exposure to low levels of aluminum leads to changes associated with brain aging and neurodegeneration.

Toxicology (2013-11-06)
Stephen C Bondy
ABSTRACT

Aluminum is one of the most common metal elements in the earth's crust. It is not an essential element for life and has commonly been thought of as a rather inert and insoluble mineral. Therefore, it has often been regarded as not posing a significant health hazard. In consequence, aluminum-containing agents been used in many food processing steps and also in removal by flocculation of particulate organic matter from water. In recent years, acid rain has tended to mobilize aluminum-containing minerals into a more soluble form, ionic Al(3+), which has found their way into many reservoirs that constitute residential drinking water resources. As a result, the human body burden of aluminum has increased. Epidemiological studies suggest that aluminum may not be as innocuous as was previously thought and that aluminum may actively promote the onset and progression of Alzheimer's disease. Epidemiological data is strengthened by experimental evidence of aluminum exposure leading to excess inflammatory activity within the brain. Such apparently irrelevant immune activity unprovoked by an exogenous infectious agent characterizes the aging brain and is even more pronounced in several neurodegenerative diseases. The causation of most of these age-related neurological disorders is not understood but since they are generally not genetic, one must assume that their development is underlain by unknown environmental factors. There is an increasing and coherent body of evidence that implicates aluminum as being one such significant factor. Evidence is outlined supporting the concept of aluminum's involvement in hastening brain aging. This acceleration would then inevitably lead to increased incidence of specific age-related neurological diseases.

MATERIALS
Product Number
Brand
Product Description

Aluminum, wire reel, 5m, diameter 0.025mm, as drawn, 99.0+%
Aluminum, wire reel, 5m, diameter 0.25mm, as drawn, 99.999%
Aluminum, wire reel, 50m, diameter 0.25mm, hard, 99.99+%
Aluminum, wire reel, 5m, diameter 1.0mm, as drawn, 99.999%
Aluminum, wire reel, 50m, diameter 1.0mm, as drawn, 99.95+%
Aluminum, wire reel, 5m, diameter 0.125mm, as drawn, 99.99+%
Aluminum, wire reel, 5m, diameter 1.5mm, as drawn, 99.999%
Aluminum, wire reel, 50m, diameter 0.063mm, annealed, 99.99%
Aluminum, wire reel, 5m, diameter 0.05mm, as drawn, 99.99+%
Aluminum, wire reel, 5m, diameter 2.0mm, as drawn, 99.999%
Aluminum, wire reel, 50m, diameter 0.5mm, as drawn, 99.5%
Aluminum, microleaf disks, 25mm, thinness 1.0μm, specific density 269.9μg/cm2, removable support, 99.999%
Aluminum, tube, 0.1m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%
Aluminum, rod, 200mm, diameter 5.0mm, as drawn, 99.999%
Aluminum, tube, 200mm, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, as drawn, 99.5%
Aluminum, microleaf disks, 10mm, thinness 1.0μm, specific density 269.9μg/cm2, removable support, 99.999%
Aluminum, rod, 500mm, diameter 15.0mm, as drawn, 99.999%
Aluminum, rod, 100mm, diameter 20.0mm, as drawn, 99.999%
Aluminum, rod, 50mm, diameter 28mm, as drawn, 99.999%
Aluminum, microfoil, disks, 50mm, thinness 1.0μm, specific density 269.9μg/cm2, permanent mylar 3.5μm support, 99.999%
Aluminum, tube, 100mm, outside diameter 0.55mm, inside diameter 0.4mm, wall thickness 0.075mm, as drawn, 99.5%
Aluminum, rod, 44mm, diameter 77.5mm, as drawn, 99.999%
Aluminum, microleaf disks, 25mm, thinness 0.15μm, specific density 41.28μg/cm2, removable support, 99.999%
Aluminum, rod, 500mm, diameter 5.0mm, as drawn, 99.999%
Aluminum, tube, 200mm, outside diameter 0.86mm, inside diameter 0.76mm, wall thickness 0.05mm, as drawn, 99.5%
Aluminum, microfoil, disks, 25mm, thinness 0.0075μm, specific density 1.84μg/cm2, permanent mylar 3.5μm support, 99.999%
Aluminum, mesh, 150x150mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh
Aluminum, tube, 0.5m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%
Aluminum, tube, 100mm, outside diameter 0.6mm, inside diameter 0.3mm, wall thickness 0.15mm, as drawn, 99.5%
Aluminum, rod, 100mm, diameter 12.0mm, as drawn, 99.999%