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The role of iron and reactive oxygen species in cell death.

The role of iron and reactive oxygen species in cell death.

Nature chemical biology (2013-12-19)

Scott J Dixon, Brent R Stockwell

ABSTRACT

The transition metal iron is essential for life, yet potentially toxic iron-catalyzed reactive oxygen species (ROS) are unavoidable in an oxygen-rich environment. Iron and ROS are increasingly recognized as important initiators and mediators of cell death in a variety of organisms and pathological situations. Here, we review recent discoveries regarding the mechanism by which iron and ROS participate in cell death. We describe the different roles of iron in triggering cell death, targets of iron-dependent ROS that mediate cell death and a new form of iron-dependent cell death termed ferroptosis. Recent advances in understanding the role of iron and ROS in cell death offer unexpected surprises and suggest new therapeutic avenues to treat cancer, organ damage and degenerative disease.

MATERIALS

Product Number

Brand

Product Description

Iron, IRMM^®, certified reference material, 0.5 mm wire

Sigma-Aldrich

Iron, powder, −325 mesh, 97%

Sigma-Aldrich

Iron, foil, thickness 0.1 mm, ≥99.9% trace metals basis

Sigma-Aldrich

Iron, chips, 99.98% trace metals basis

Iron, foil, 15mm disks, thickness 0.008mm, 99.85%

Iron, foil, 15mm disks, thickness 0.25mm, hard, 99.5%

Iron, foil, 15mm disks, thickness 0.020mm, 99.85%

Iron, foil, 10mm disks, thickness 0.075mm, hard, 99.5%

Iron, foil, 10mm disks, thickness 0.38mm, hard, 99.5%

Iron, foil, 4mm disks, thickness 0.025mm, as rolled, 99.99+%

Iron, foil, 25mm disks, thickness 0.003mm, 99.85%

Iron, foil, 1m coil, thickness 0.1mm, hard, 99.5%

Iron, foil, 10mm disks, thickness 0.125mm, as rolled, 99.99+%

Iron, foil, 1m coil, thickness 0.025mm, hard, 99.5%

Iron, foil, 25mm disks, thickness 0.004mm, 99.85%

Iron, foil, 2m coil, thickness 0.38mm, hard, 99.5%

Iron, foil, 15mm disks, thickness 0.038mm, hard, 99.5%

Iron, foil, 10mm disks, thickness 0.9mm, as rolled, 99.5%

Iron, foil, 4mm disks, thickness 0.009mm, 99.85%

Iron, foil, 2m coil, thickness 0.025mm, hard, 99.5%

Iron, foil, 15mm disks, thickness 0.0125mm, 99.85%

Iron, foil, 10mm disks, thickness 0.125mm, hard, 99.5%

Iron, foil, 20m coil, thickness 0.038mm, hard, 99.5%

Iron, foil, 10mm disks, thickness 1.0mm, as rolled, 99.5%

Iron, foil, 25mm disks, thickness 0.009mm, 99.85%

Iron, foil, 4mm disks, thickness 0.008mm, 99.85%

Iron, foil, 2m coil, thickness 0.038mm, hard, 99.5%

Iron, foil, 25mm disks, thickness 0.020mm, 99.85%

Iron, foil, 4mm disks, thickness 0.5mm, hard, 99.5%

Iron, foil, 10mm disks, thickness 0.15mm, hard, 99.5%