Skip to Content
MilliporeSigma
  • Nephrogenic diabetes insipidus persisting 57 months after cessation of lithium carbonate therapy: report of a case and review of the literature.

Nephrogenic diabetes insipidus persisting 57 months after cessation of lithium carbonate therapy: report of a case and review of the literature.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists (2001-03-10)
A F Guirguis, H C Taylor
ABSTRACT

To illuminate the natural history of prolonged nephrogenic diabetes insipidus after discontinuation of lithium carbonate treatment and to assess the response to therapy with desmopressin acetate and triamterene-hydrochlorothiazide. We analyzed sequential determinations of serum and urine osmolality, plasma arginine vasopressin, serum sodium, blood urea nitrogen, calcium, ionized calcium, parathyroid hormone, and 24-hour urine volume during a period of 57 months in a 67-year-old woman. Our patient experienced persistent polyuria in conjunction with having repeated serum osmolalities between 300 and 323 mOsm/kg and urine osmolalities between 130 and 208 mOsm/kg. Concomitant plasma arginine vasopressin levels were as high as 12.0 pg/mL, consistent with the diagnosis of nephrogenic diabetes insipidus. Administration of triamterene-hydrochlorothiazide reduced 24-hour urine volume and serum osmolality while increasing urine osmolality. Desmopressin acetate exhibited no effect. In this report, we describe the eighth documented case of persistent nephrogenic diabetes insipidus, lasting 57 months after cessation of lithium therapy, and demonstrate a palliative effect of triamterene-hydrochlorothiazide.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Lithium carbonate, 99.997% trace metals basis
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
500 g
In Stock
Details...
$77.70
1 kg
In Stock
Details...
$136.00
Sigma-Aldrich
Lithium carbonate, 99.999% trace metals basis
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
500 g
In Stock
Details...
$77.70
1 kg
In Stock
Details...
$136.00
Sigma-Aldrich
Lithium carbonate, puriss. p.a., ACS reagent, reagent (for microscopy), ≥99.0% (T)
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
500 g
In Stock
Details...
$77.70
1 kg
In Stock
Details...
$136.00
Sigma-Aldrich
Lithium carbonate, ACS reagent, ≥99.0%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
500 g
In Stock
Details...
$77.70
1 kg
In Stock
Details...
$136.00