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Merck

Adapalene: a review of its use in the treatment of acne vulgaris.

Drugs (2004-06-24)
John Waugh, Stuart Noble, Lesley J Scott
ABSTRACT

Adapalene (Differin) is a retinoid agent indicated for the topical treatment of acne vulgaris. In clinical trials, 0.1% adapalene gel has proved to be effective in this indication and was as effective as 0.025% tretinoin gel, 0.1% tretinoin microsphere gel, 0.05% tretinoin cream and 0.1% tazarotene gel once every two days; however, the drug was less effective than once-daily 0.1% tazarotene gel. It can be used alone in mild acne or in combination with antimicrobials in inflammatory acne and has proved efficacious as maintenance treatment. Adapalene has a rapid onset of action and a particularly favourable tolerability profile compared with other retinoids. These attributes can potentially promote patient compliance, an important factor in treatment success. Adapalene is, therefore, assured of a role in the first-line treatment of acne vulgaris.

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Sigma-Aldrich
Adapalene, ≥98% (HPLC)
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Adapalene, European Pharmacopoeia (EP) Reference Standard
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Adapalene for peak identification, European Pharmacopoeia (EP) Reference Standard
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USP
Adapalene, United States Pharmacopeia (USP) Reference Standard
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Supelco
Adapalene, Pharmaceutical Secondary Standard; Certified Reference Material
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