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  • The rise of metal radionuclides in medical imaging: copper-64, zirconium-89 and yttrium-86.

The rise of metal radionuclides in medical imaging: copper-64, zirconium-89 and yttrium-86.

Future medicinal chemistry (2011-04-30)
Oluwatayo F Ikotun, Suzanne E Lapi
ABSTRACT

Positron emission tomography, with its high sensitivity and resolution, is growing rapidly as an imaging technology for the diagnosis of many disease states. The success of this modality is reliant on instrumentation and the development of effective and novel targeted probes. Initially, research in this area was focused on what we will define in this article as 'standard' PET isotopes (carbon-11, nitrogen-13, oxygen-15 and fluorine-18), but the short half-lives of these isotopes limit radiopharmaceutical development to those that probe rapid biological processes. To overcome these limitations, there has been a rise in nonstandard isotope probe development in recent years. This review focuses on the biological probes and processes that have been examined, in additiom to the preclinical and clinical findings with nonstandard radiometals: copper-64, zirconium-89, and yttrium-86.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Zirconium, foil, thickness 0.1 mm, 99.98% trace metals basis
Sigma-Aldrich
Zirconium, rod, diam. 6.35 mm, ≥99% trace metals basis
Sigma-Aldrich
Zirconium, sponge, ≥99% trace metals basis
Sigma-Aldrich
Zirconium, powder, −100 mesh
Zirconium, tube, 100mm, outside diameter 2.0mm, inside diameter 1.6mm, wall thickness 0.2mm, annealed, 99.2%
Zirconium, wire reel, 0.5m, diameter 0.05mm, as drawn, 99.2%
Zirconium, tube, 1000mm, outside diameter 6.35mm, inside diameter 4.55mm, wall thickness 0.9mm, annealed, 99.2%
Zirconium, wire reel, 5m, diameter 0.25mm, as drawn, 99.2%
Zirconium, rod, 100mm, diameter 6.0mm, centerless ground, 99.2%
Zirconium, tube, 200mm, outside diameter 6.35mm, inside diameter 4.55mm, wall thickness 0.9mm, annealed, 99.2%
Zirconium, wire reel, 5m, diameter 0.28mm, annealed, 99.2%
Zirconium, wire reel, 10m, diameter 0.25mm, as drawn, 99.2%
Zirconium, rod, 500mm, diameter 1.5mm, 99.2%
Zirconium, tube, 200mm, outside diameter 2.0mm, inside diameter 1.6mm, wall thickness 0.2mm, annealed, 99.2%
Zirconium, rod, 200mm, diameter 12.7mm, centerless ground, 99.2%
Zirconium, wire reel, 5m, diameter 0.5mm, as drawn, 99.2%
Zirconium, sponge, 50g, max. size 25mm, 99.2%
Zirconium, rod, 100mm, diameter 9.5mm, centerless ground, 99.2%
Zirconium, rod, 500mm, diameter 6.0mm, centerless ground, 99.2%
Zirconium, rod, 100mm, diameter 19.0mm, centerless ground, 99.2%
Zirconium, rod, 1000mm, diameter 12.7mm, centerless ground, 99.2%
Zirconium, rod, 1000mm, diameter 9.5mm, centerless ground, 99.2%
Zirconium, rod, 1000mm, diameter 1.5mm, 99.2%
Zirconium, rod, 1000mm, diameter 2.0mm, centerless ground, 99.2%
Zirconium, wire reel, 10m, diameter 0.28mm, annealed, 99.2%
Zirconium, rod, 100mm, diameter 2.0mm, centerless ground, 99.2%
Zirconium, wire reel, 20m, diameter 0.25mm, as drawn, 99.2%
Zirconium, rod, 500mm, diameter 9.5mm, centerless ground, 99.2%
Zirconium, sponge, 100g, max. size 25mm, 99.2%
Zirconium, tube, 100mm, outside diameter 1.6mm, inside diameter 1.1mm, wall thickness 0.25mm, hard, 99.2%