MilliporeSigma

PET tracers based on Zirconium-89.

Current radiopharmaceuticals (2011-12-24)
Yin Zhang, Hao Hong, Weibo Cai
ABSTRACT

Positron emission tomography (PET) imaging with radiolabeled monoclonal antibodies has always been a dynamic area in molecular imaging. With decay half-life (3.3 d) well matched to the circulation half-lives of antibodies (usually on the order of days), (89)Zr has been extensively studied over the last decade. This review article will give a brief overview on (89)Zr isotope production, the radiochemistry generally used for (89)Zr-labeling, and the PET tracers that have been developed using (89)Zr. To date, (89)Zr-based PET imaging has been investigated for a wide variety of cancer-related targets, which include human epidermal growth factor receptor 2, epidermal growth factor receptor, prostate-specific membrane antigen, splice variant v6 of CD44, vascular endothelial growth factor, carbonic anhydrase IX, insulin-like growth factor 1 receptor, among others. With well-developed radiochemistry, commercial availability of chelating agents for (89)Zr labeling, increasingly widely available isotope supply, as well as successful proof-of-principle in pilot human studies, it is expected that PET imaging with (89)Zr-based tracers will be a constantly evolving and highly vibrant field in the near future.

MATERIALS
Product Number
Brand
Product Description

Zirconium, foil, light tested, 100x100mm, thickness 0.025mm, annealed, 99.2%
Zirconium, foil, 6mm disks, thickness 0.009mm, 99.2%
Zirconium, foil, 8mm disks, thickness 0.01mm, 99.2%
Zirconium, foil, not light tested, 150x150mm, thickness 0.0125mm, 99.2%
Zirconium, foil, light tested, 300x300mm, thickness 0.05mm, annealed, 99.2%
Zirconium, foil, 6mm disks, thickness 0.015mm, 99.2%
Zirconium, foil, light tested, 50x50mm, thickness 0.006mm, 99.2%
Zirconium, foil, not light tested, 25x25mm, thickness 0.006mm, 99.2%
Zirconium, foil, light tested, 25x25mm, thickness 0.008mm, 99.2%
Zirconium, foil, light tested, 50x50mm, thickness 0.015mm, 99.2%
Zirconium, foil, not light tested, 50x50mm, thickness 0.0025mm, 99.2%
Zirconium, foil, 8mm disks, thickness 0.5mm, annealed, 99.2%
Zirconium, foil, 8mm disks, thickness 0.025mm, annealed, 99.2%
Zirconium, foil, light tested, 50x50mm, thickness 0.02mm, 99.2%
Zirconium, foil, not light tested, 150x150mm, thickness 0.009mm, 99.2%
Zirconium, foil, light tested, 50x50mm, thickness 0.007mm, 99.2%
Zirconium, foil, not light tested, 200x300mm, thickness 0.02mm, 99.2%
Zirconium, foil, 4mm disks, thickness 0.25mm, annealed, 99.2%
Zirconium, foil, 50mm disks, thickness 0.02mm, 99.2%
Zirconium, foil, 4mm disks, thickness 0.0125mm, 99.2%
Zirconium, foil, light tested, 25x25mm, thickness 0.009mm, 99.2%
Zirconium, foil, light tested, 100x100mm, thickness 0.007mm, 99.2%
Zirconium, foil, light tested, 50x50mm, thickness 0.05mm, annealed, 99.2%
Zirconium, foil, light tested, 150x150mm, thickness 0.075mm, annealed, 99.2%
Zirconium, foil, not light tested, 25x25mm, thickness 0.001mm, 99.2%
Zirconium, foil, light tested, 100x100mm, thickness 0.05mm, annealed, 99.2%
Zirconium, foil, light tested, 200x300mm, thickness 0.02mm, 99.2%
Zirconium, foil, 4mm disks, thickness 0.009mm, 99.2%
Zirconium, foil, not light tested, 50x50mm, thickness 0.003mm, 99.2%
Zirconium, foil, not light tested, 50x50mm, thickness 0.002mm, 99.2%