Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Journal of inorganic biochemistry (2012-07-24)

A G Quiroga

PMID22819649

ABSTRACT

This focused review is devoted to our advances in developing trans platinum complexes as antitumoral complexes, in particular those bearing aliphatic amines. It includes some fundamental aspects of the understanding of non conventional metallodrug mechanism. The perspective is arranged by those fundamental aspects and within each section only the most successful examples have been included and also those in which clearly SAR's (structure activity relationships) have been observed.

MATERIALS

Product Number

Brand

Product Description

267163

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.99% trace metals basis

357367

Sigma-Aldrich

Platinum, wire, diam. 0.10 mm, 99.99% trace metals basis

267201

Sigma-Aldrich

Platinum, wire, diam. 0.5 mm, 99.99% trace metals basis

267228

Sigma-Aldrich

Platinum, wire, diam. 0.5 mm, 99.9% trace metals basis

267171

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.99% trace metals basis

267260

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Platinum, foil, thickness 0.5 mm, 99.99% trace metals basis

267155

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685453

Sigma-Aldrich

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327433

Sigma-Aldrich

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349372

Sigma-Aldrich

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349364

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.99% trace metals basis

349356

Sigma-Aldrich

Platinum, foil, thickness 0.05 mm, 99.99% trace metals basis

373265

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349399

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204048

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357359

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298107

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373214

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204013

Sigma-Aldrich

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303798

Sigma-Aldrich

Platinum, foil, thickness 0.05 mm, ≥99.9% trace metals basis

GF47679698

Platinum, wire reel, 20m, diameter 0.05mm, hard, 99.99%

327492

Sigma-Aldrich

Platinum, wire, diam. 1.0 mm, 99.9% trace metals basis

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Platinum, foil, 0.1m coil, thickness 0.045mm, coil width .75mm, as rolled, 99.95%

GF66347736

Platinum, foil, 0.05m coil, thickness 0.025mm, coil width 2mm, as rolled, 99.95%

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Platinum, foil, 0.2m coil, thickness 0.025mm, coil width 2mm, as rolled, 99.95%

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Platinum, foil, 0.5m coil, thickness 0.05mm, coil width 1mm, as rolled, 99.99%

GF05410303

Platinum, foil, not light tested, 25x25mm, thickness 0.0125mm, as rolled, 99.95%

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Platinum, wire reel, 0.2m, diameter 0.40mm, as drawn, 99.99%

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Platinum, foil, 15mm disks, thickness 0.0075mm, as rolled, 99.95%

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Platinum, foil, not light tested, 25x25mm, thickness 0.00125mm, as rolled, 99.95%