Ocular manifestations of monoclonal copper-binding immunoglobulin.

Ocular manifestations of monoclonal copper-binding immunoglobulin.

Survey of ophthalmology (2013-10-12)

Sejal Shah, Edgar M Espana, Curtis E Margo

ABSTRACT

The dense accumulation of copper in Descemet membrane and lens capsule is the characteristic manifestation of a circulating monoclonal antibody with strong affinity for copper. The overproduction of this monoclonal immunoglobulin may be associated with either multiple myeloma or a benign monoclonal gammopathy. Despite prolonged exposure to elevated serum copper, no other tissues in the body are adversely affected by this redox metal. We describe the clinical and pathological findings in a 46-year-old woman with this disorder.

MATERIALS

Product Number

Brand

Product Description

61139

Sigma-Aldrich

Copper, turnings, purum p.a., ≥99.0%

266744

Sigma-Aldrich

Copper, foil, thickness 1.0 mm, 99.999% trace metals basis

207780

Sigma-Aldrich

Copper, powder, <75 μm, 99%

349216

Sigma-Aldrich

Copper, wire, diam. 1.0 mm, ≥99.9%

349208

Sigma-Aldrich

Copper, foil, thickness 0.025 mm, 99.98% trace metals basis

326488

Sigma-Aldrich

Copper, beads, 2-8 mm, ≥99.99% trace metals basis

326429

Sigma-Aldrich

Copper, wire, diam. 0.25 mm, 99.999% trace metals basis

349224

Sigma-Aldrich

Copper, wire, diam. 2.0 mm, 99.999% trace metals basis

254177

Sigma-Aldrich

Copper, beads, 2-8 mm, 99.9995% trace metals basis

349151

Sigma-Aldrich

Copper, foil, thickness 0.5 mm, 99.98% trace metals basis

326410

Sigma-Aldrich

Copper, wire, diam. 0.64 mm, 99.995% trace metals basis

12816

Sigma-Aldrich

Copper, foil, ≥99.8% (complexometric)

BCR058

Continuous cast copper (O), BCR^®, certified reference material, rod

GF98944600

Copper - O.F.H.C., foil, 25mm disks, thickness 0.025mm, hard, 99.95+%

GF93468325

Copper, wire reel, 0.2m, diameter 0.1mm, aluminum cladding, outside diameter 0.25mm, 99.9%

GF85994904

Copper, wire reel, 200m, diameter 0.5mm, annealed, silver plated, 99.9%

GF66965956

Copper, wire reel, 1000m, diameter 0.125mm, annealed, 99.9%

GF90200742

Copper, wire reel, 1m, diameter 0.01mm, hard, 99.99%

GF85570678

Copper, wire reel, 2000m, diameter 0.075mm, annealed, 99.9%

GF89712333

Copper, wire reel, 100m, diameter 0.5mm, as drawn, 99.98+%

GF74334809

Copper, wire reel, 2m, diameter 0.75mm, as drawn, 99.98+%

GF97778558

Copper, wire reel, 500m, diameter 0.15mm, annealed, silver plated, 99.9%

GF93417105

Copper, wire reel, 100m, diameter 1.0mm, as drawn, 99.98+%

GF86528155

Copper, wire reel, 100m, diameter 0.05mm, annealed, 99.9%

GF68805760

Copper, wire reel, 50m, diameter 0.25mm, as drawn, 99.99+%

GF87182657

Copper, tube, 1000mm, outside diameter 6.0mm, inside diameter 4mm, wall thickness 1.0mm, as drawn, 99.9%

GF93436926

Copper, tube, 1000mm, outside diameter 0.95mm, inside diameter 0.29mm, wall thickness 0.33mm, as drawn, 99.9%

GF98886920

Copper, rod, 50mm, diameter 12.7mm, as drawn, 99.99+%

GF96361263

Copper - O.F.H.C., foil, 100x100mm, thickness 0.1mm, half hard, 99.95+%

GF98511554

Copper - O.F.H.C., foil, 10m coil, thickness 0.025mm, hard, 99.95+%