- Synthesis and evaluation of biological properties of benzylideneacetophenone derivatives.
Synthesis and evaluation of biological properties of benzylideneacetophenone derivatives.
Archives of pharmacal research (2006-07-13)
Seikwan Oh, Soyong Jang, Donghyun Kim, Inn-Oc Han, Jae-Chul Jung
PMID16833013
ABSTRACT
A series of yakuchinone B 1f and its analogs 1a-e was synthesized and evaluated for free radical scavenging, suppression of LPS-induced NO generation, cytotoxicity and anti-excitotoxicity in vitro. Compound 1c exhibited potent anti-excitotoxicity, while all compounds 1a-f showed considerable effects of free radical scavenging, suppression of LPS-induced NO generation, and cytotoxicity in microglia.
MATERIALS