- Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis.
Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy (1998-05-21)
G J Alangaden, B N Kreiswirth, A Aouad, M Khetarpal, F R Igno, S L Moghazeh, E K Manavathu, S A Lerner
PMID9593173
ABSTRACT
An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 microg/ml). High-level cross-resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.
MATERIALS