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  • Meta-analyses between 18 candidate genetic markers and overweight/obesity.

Meta-analyses between 18 candidate genetic markers and overweight/obesity.

Diagnostic pathology (2014-03-14)
Linlin Tang, Huadan Ye, Qingxiao Hong, Fei Chen, Qinwen Wang, Leiting Xu, Shizhong Bu, Qiong Liu, Meng Ye, Dao Wen Wang, Yifeng Mai, Shiwei Duan
ABSTRACT

The goal of our study is to investigate the associations between 18 candidate genetic markers and overweight/obesity. A total of 72 eligible articles were retrieved from literature databases including PubMed, Embase, SpingerLink, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang. Meta-analyses of 18 genetic markers among 56,738 controls and 48,148 overweight/obese persons were done by Review Manager 5.0. Our results showed that SH2B1 rs7498665 polymorphism was significantly associated with the risk of overweight/obesity (overall odds ratio (OR) = 1.21, 95% confidence interval (CI) = 1.09-1.34, P = 0.0004). Increased risk of overweight/obesity was also observed in FAIM2 rs7138803 polymorphism (overall OR = 1.11, 95% CI = 1.01-1.22, P = 0.04). Our meta-analyses have shown the important role of 2 polymorphisms (SH2B1 rs7498665 and FAIM2 rs7138803) in the development of overweight/obesity. This study highlighted the importance of above two candidate genes (SH2B1 and FAIM2) in the risk of overweight/obesity. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2785487401176182.