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  • Recent advances towards the fabrication and biomedical applications of responsive polymeric assemblies and nanoparticle hybrid superstructures.

Recent advances towards the fabrication and biomedical applications of responsive polymeric assemblies and nanoparticle hybrid superstructures.

Dalton transactions (Cambridge, England : 2003) (2015-01-13)
Xianglong Hu, Shiyong Liu
ABSTRACT

Responsive polymeric assemblies and hybrid superstructures fabricated from stimuli-sensitive polymers and inorganic nanoparticles (NPs) have been the subject of extensive investigations during the past few decades due to their distinct advantages such as an improved water solubility, stimuli-responsiveness, excellent biocompatibility, and facile introduction of functional units. In addition, the chemical compositions of polymeric assemblies and corresponding hybrid superstructures can be modulated via the initial synthetic design to target desired functions, fabricate smart nanostructures, and explore morphology-dependent functional optimization. Promising applications in the field of imaging, sensing, drug/gene delivery, diagnostics, and nanoreactors are being extensively investigated. This perspective article focuses on recent developments, microstructural control, and biomedical applications of stimuli-responsive polymeric assemblies as well as responsive hybrid superstructures fabricated from responsive polymers and inorganic NP building blocks (gold NPs and magnetic iron oxide NPs), and highlights their current status and future developments with selected literature reports.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Iron oxide (II,III), nanopowder, 25 nm, NHS ester functionalized
Sigma-Aldrich
Iron oxide (II,III), nanoparticles, 5 nm avg. part. size (TEM), 5 mg/mL in chloroform
Sigma-Aldrich
Iron oxide (II,III), nanoparticles, 15 nm avg. part. size (TEM), PEG functionalized, 1 mg/mL in H2O
Sigma-Aldrich
Iron oxide (II,III), nanoparticles, 30 nm avg. part. size (TEM), 5 mg/mL in H2O
Sigma-Aldrich
Iron oxide (II,III), nanoparticles, 25 nm avg. part. size (TEM), 5 mg/mL in H2O
Sigma-Aldrich
Iron oxide (II,III), nanoparticles, 25 nm avg. part. size (TEM), 5 mg/mL in toluene
Sigma-Aldrich
Iron oxide (II,III), nanoparticles, 20 nm avg. part. size (TEM), 5 mg/mL in chloroform
Sigma-Aldrich
Iron oxide (II,III), nanoparticles, 10 nm avg. part. size (TEM), 5 mg/mL in chloroform
Sigma-Aldrich
Iron oxide (II,III), nanoparticles, 15 nm avg. part. size (TEM), streptavidin functionalized, 1 mg/mL in H2O
Sigma-Aldrich
Iron oxide (II,III), nanoparticles, 15 nm avg. part. size (TEM), 5 mg/mL in H2O
Sigma-Aldrich
Iron oxide (II,III), nanoparticles, 30 nm avg. part. size (TEM), streptavidin functionalized, 1 mg/mL in H2O
Sigma-Aldrich
Iron oxide (II,III), nanoparticles, 15 nm avg. part. size (TEM), carboxylic acid functionalized, 5 mg/mL in H2O
Sigma-Aldrich
Iron oxide (II,III), nanoparticles, 10 nm avg. part. size (TEM), streptavidin functionalized, 1 mg/mL in H2O