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  • Epstein-Barr virus infection of human brain microvessel endothelial cells: a novel role in multiple sclerosis.

Epstein-Barr virus infection of human brain microvessel endothelial cells: a novel role in multiple sclerosis.

Journal of neuroimmunology (2010-09-10)
Costanza Casiraghi, Katerina Dorovini-Zis, Marc S Horwitz
ABSTRACT

Multiple sclerosis (MS) is an inflammatory neurological disease that is widely regarded as the outcome of complex interactions between a genetic predisposition and an environmental trigger. Epstein-Barr virus (EBV) has recently been associated with the onset of MS, yet understanding how it elicits autoimmunity remains elusive. Neuroinflammation, including the entry of autoreactive T cells, likely follows a breach of the blood-brain barrier (BBB) leading to CNS lesions in MS. We show that EBV can infect human BBB cells leading to increased production of pro-inflammatory mediators that result in immune cell adherence thus modeling a key step in MS pathogenesis.

MATERIALS
Product Number
Brand
Product Description

Roche
Pwo SuperYield DNA Polymerase, suitable for PCR, Difficult Templates/Specialty Enzymes PCR, hotstart: no, dNTPs included: no