- Multimodal image-guided enzyme/prodrug cancer therapy.
Multimodal image-guided enzyme/prodrug cancer therapy.
Journal of the American Chemical Society (2006-11-23)
Cong Li, Paul T Winnard, Tomoyo Takagi, Dmitri Artemov, Zaver M Bhujwalla
PMID17117842
ABSTRACT
The conjugate of bacterial cytosine deaminase (bCD) and poly-l-lysine (PLL) that was functionalized with biotin, rhodamine, and Gd3+-DOTA was synthesized and characterized. It demonstrated high relaxivity, improved enzymatic specificity to prodrug 5-fluorocytosine, low cytotoxicity, efficient cell uptake, and high enzymatic stability in fresh mouse serum and human breast cancer cell culture.
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