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Gold-catalyzed synthesis of substituted tetrahydronaphthalenes.

Organic letters (2006-12-01)
Christiane M Grisé, Louis Barriault
ABSTRACT

We report a gold-catalyzed benzannulation of 3-hydroxy-1,5-enynes to generate tetrahydronaphthalenes. This mild process proves to be an effective method to synthesize various metasubstituted aromatic rings in good yields. [reaction: see text]

MATERIALS
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Product Description

Sigma-Aldrich
1-Propynylmagnesium bromide solution, 0.5 M in THF