- Transcriptional dysregulation causes altered modulation of inhibition by haloperidol.
Transcriptional dysregulation causes altered modulation of inhibition by haloperidol.
Neuropharmacology (2016-08-03)
Lillian J Brady, Aundrea F Bartley, Qin Li, Laura J McMeekin, John J Hablitz, Rita M Cowell, Lynn E Dobrunz
PMID27480797
ABSTRACT
Many neuropsychiatric and neurodevelopmental disorders such as schizophrenia and autism involve interneuron transcriptional dysregulation. The transcriptional coactivator PGC-1α regulates gene expression in GABAergic interneurons, which are important for regulating hippocampal network activity. Genetic deletion of PGC-1α causes a decrease in parvalbumin expression, similar to what is observed in schizophrenia postmortem tissue. Our lab has previously shown that PGC-1α
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