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  • Miniature surface-plasmon resonance immunosensors--rapid and repetitive procedure.

Miniature surface-plasmon resonance immunosensors--rapid and repetitive procedure.

Analytical and bioanalytical chemistry (2002-04-09)
Masayasu Suzuki, Fumihiko Ozawa, Wakako Sugimoto, Shuji Aso
ABSTRACT

Miniaturized immunosensors based on surface-plasmon resonance (SPR) have been developed by using the sensor recently developed by Texas Instruments. By using this sensor for human immunoglobulin G (IgG) rapid and repetitive measurements could be performed by alternate injection of sample and glycine-HCl buffer. A sensor for human serum albumin (HSA) could also be developed similarly. One difficulty in immunosensor development is dissociation of the strongly bound antigen-antibody complex. A "regenerable" immunosensor has also been developed for this reason.

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Sigma-Aldrich
Protein A from Staphylococcus aureus, Soluble, essentially salt-free, lyophilized powder, extracellular