Inhalable Ipratropium Bromide Particle Engineering with Multicriteria Optimization.

Inhalable Ipratropium Bromide Particle Engineering with Multicriteria Optimization.

AAPS PharmSciTech (2016-11-23)

Bhavani Prasad Vinjamuri, Rahul V Haware, William C Stagner

ABSTRACT

Spray-dried ipratropium bromide (IPB) microspheres for oral inhalation were engineered using Quality by Design. The interrogation of material properties, process parameters, and critical product quality attributes interplay enabled rational product design. A 2

MATERIALS

Product Number

Brand

Product Description

438243

Sigma-Aldrich

Tetrapropylammonium chloride, 98%

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