- Recurrent rhinovirus infections in a child with inherited MDA5 deficiency.
Recurrent rhinovirus infections in a child with inherited MDA5 deficiency.
MDA5 is a cytosolic sensor of double-stranded RNA (ds)RNA including viral byproducts and intermediates. We studied a child with life-threatening, recurrent respiratory tract infections, caused by viruses including human rhinovirus (HRV), influenza virus, and respiratory syncytial virus (RSV). We identified in her a homozygous missense mutation in