- S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis.
S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis.
Oncotarget (2017-11-08)
Maria Lauda Tomasi, Carla Cossu, Ylenia Spissu, Andrea Floris, Minjung Ryoo, Ainhoa Iglesias-Ara, Qiang Wang, Stephen J Pandol, Neil A Bhowmick, Ekihiro Seki, Edwin M Posadas, Shelly C Lu
PMID29108270
ABSTRACT
MicroRNA-34a (miR-34a) is down-regulated in colorectal cancers (CRC) and required for interleukin-6 (IL-6)-induced CRC metastasis. Mice lacking miR-34a developed more invasive cancer in a colitis-associated cancer model. In the same model, S-adenosylmethionine (SAMe) and methylthioadenosine (MTA) inhibited IL-6/STAT3 and lowered tumor burden. SAMe and MTA reduce the expression of methionine adenosyltransferase 2A (MAT2A) and there are consensus binding sites for miR-34a/b in the