- Overexpression of SYF2 promotes cell proliferation and correlates with poor prognosis in human breast cancer.
Overexpression of SYF2 promotes cell proliferation and correlates with poor prognosis in human breast cancer.
Oncotarget (2017-11-29)
Feng Shi, Feng-Feng Cai, Lu Cai, Xiao-Yan Lin, Wei Zhang, Qin-Qin Wang, Yu-Jie Zhao, Qi-Chao Ni, Hua Wang, Zhi-Xian He
PMID29179448
ABSTRACT
SYF2, a known cell cycle regulator, is reported to be involved in cell cycle arrest by interacting with cyclin-D-type binding protein 1. In the present study, we investigated the role of SYF2 in human breast cancer (BC) progression. SYF2 was highly upregulated in BC tissues and cell lines, as per Western blot and immunohistochemistry analysis. The SYF2 expression level had a significant correlation with the tumor grade and Ki-67 expression.
MATERIALS