- KIF1Bβ increases ROS to mediate apoptosis and reinforces its protein expression through O
KIF1Bβ increases ROS to mediate apoptosis and reinforces its protein expression through O
Scientific reports (2017-12-06)
Clara Angelina, Irene Sze Ying Tan, Zhang'e Choo, Oswald Zhao Jian Lee, Shazib Pervaiz, Zhi Xiong Chen
PMID29203804
ABSTRACT
Relapse-prone, poor prognosis neuroblastoma is frequently characterized by deletion of chr1p36 where tumor suppressor gene KIF1Bβ resides. Interestingly, many 1p36-positive patients failed to express KIF1Bβ protein. Since altered cellular redox status has been reported to be involved in cell death and protein modification, we investigated the relationship between reactive oxygen species (ROS) and KIF1Bβ. Here, we showed that wild-type KIF1Bβ protein expression positively correlates with superoxide (O