Synthesis Made Synple – Synple Automatic Synthesizer & Reagent Cartridges

As a leading supplier of reagents and tools for chemical synthesis, we are continuously expanding our portfolio of innovative products to enhance and facilitate your research. Now, we’ve partnered with Synple Chem to bring you the ingenious Synple 2: a fully automated organic chemical synthesis system that is digitized and pre-programmed to generate your research products for you. Say goodbye to manual reactions. Discover how the incredible speed and accuracy of Synple 2 can boost your lab’s productivity and accelerate your discovery.

The Synple 2 Synthesizer

Figure 1. Synple 2 synthesizer

A. Sample holder
B. Cartridge holder
C. Touchscreen
D. Cartridge scanner

The Synple 2 synthesizer contains two syringe pumps, and two rotary valves, in addition to a sample holder, cartridge holder, an RFID chip scanner, and a touchscreen. During synthesis, reactions can occur in the cartridge itself, or in the reaction vial.

Figure 2. Synple 2 reaction cartridge

A. Chemical resistant seal
B. Components preloaded with reagents
C. RFID chip programmed with reaction sequence

Synple cartridges are offered for a variety of reactions. Each cartridge contains all the reagents required to generate, isolate, and purify your product, as well as an RFID chip which is encoded with the reaction method.

Setup and Use of the Synple 2 Synthesizer

Figure 3. Simplified Synple 2 synthesizer reaction schematic

A. Valve 1
B. Pumps
C. Valve 2
D. Solvents
E. N2 Supply
F. Sample Vial
G. Waste
H. Capsule with four compartments

The setup can take as little as 5 minutes and starting your reaction can be done in 4 easy steps. First, scan the cartridge on the synthesizer to automatically load the appropriate reaction method. Although the provided methods are suitable for a broad range of starting materials, you may adjust certain parameters, such as temperature or reaction time. Then insert the cartridge into the synthesizer, add your starting material, and lastly press START.

Automatic synthesis

The starting material is prepared (e.g., dissolved), and the solution is then circulated between the vial and the first cartridge compartment for a pre-defined time. Next, it is circulated through a further number of compartments, depending on the reagents required for the reaction. During this process, the reagent is not only converted to the expected product but also isolated and purified. Once the product has been recovered, the Synple 2 performs an automated washing sequence to prepare for the next synthesis. While manual chemical synthesis can up to several hours to complete, Synple 2 just requires 5 to 10 minutes of the user’s time.

Key Features

• 5 x More Efficient
  • Fully automated organic synthesis
  • 5 minutes to set up
  • Frees your time to focus on more important experiments
• 70% Cost Savings
  • Considerably more economical than manual chemical synthesis due to lower personnel and reagent costs
• Enhanced Safety
  • Fully enclosed reaction
  • User never exposed to chemicals
  • Complies with latest safety standards
• Accurate and Convenient
  • Optimized reaction, no risk of human error
  • Compact size (W 26 cm, H 36 cm, D 49 cm)
  • Fast and easy orders through our web shop
• No Special Training Needed
  • Easy to use, requires no detailed chemistry knowledge
  • Modular system for a range of reactions at the press of a button
• 90% Less Waste
  • Fully optimized reaction sequence
  • Uses minimum reagents and solvents, greatly reducing chemical waste