HomeGene Expression & SilencingTRC Library Citations

TRC Library Citations

The MISSION® TRC1.5 human and mouse shRNA libraries are the proven performers for small-scale to high-throughput RNAi screening. Below you will find a selection of papers where researchers have published in peer-reviewed journals using the TRC1/1.5 library and have cited The Broad Institute or us as their source of high quality reagents. Unlike other shRNA libraries, the clones cited in these publications are the same clones available from us. If a specific clone is not found in our catalog, please inquire here for availability.

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How to Cite the TRC Library

In scientific publications, the human library should be referred to as MISSION® TRC-Hs 1.0 (Human) while the mouse library should be referred to as MISSION® TRC-Mm 1.0 (Mouse). If your TRC library was purchased after July 2011, the human library should be referred to as MISSION® TRC-Hs 1.5 (Human) while the mouse library should be referred to as MISSION® TRC-Mm 1.5 (Mouse). If you experimented with our TRC2 library, the human library should be referred to as MISSION® TRC-Hs 2.0 (Human) while the mouse library should be referred to as MISSION® TRC-Mm 2.0 (Mouse).Individual clones should be identified by their unique TRC number (e.g. MISSION® TRC shRNA TRCN0000030720).

MISSION® shRNA Publications

Lachke SA, Alkuraya FS, Kneeland SC, Ohn T, Aboukhalil A, Howell GR, Saadi I, Cavallesco R, Yue Y, Tsai AC, et al. 2011. Mutations in the RNA Granule Component TDRD7 Cause Cataract and Glaucoma. Science. 331(6024):1571-1576.
Sevlever D, Jiang P, Yen SC. 2008. Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of ?-Synuclein and Generation of Its Carboxy-Terminally Truncated Species?. Biochemistry. 47(36):9678-9687.
Zhang Y, Linn D, Liu Z, Melamed J, Tavora F, Young CY, Burger AM, Hamburger AW. 2008. EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance. Mol Cancer Ther. 7(10):3176-3186.
Zhang X, Varthi M, Sykes SM, Phillips C, Warzecha C, Zhu W, Wyce A, Thorne AW, Berger SL, McMahon SB. 2008. The Putative Cancer Stem Cell Marker USP22 Is a Subunit of the Human SAGA Complex Required for Activated Transcription and Cell-Cycle Progression. Molecular Cell. 29(1):102-111.
Zeng X, Huang H, Tamai K, Zhang X, Harada Y, Yokota C, Almeida K, Wang J, Doble B, Woodgett J, et al. 2008. Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions. 135(2):367-375.
Seok Yang W, Stockwell BR. 2008. Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest. Genome Biol. 9(6):R92.
Yamashita M, Kuwahara M, Suzuki A, Hirahara K, Shinnaksu R, Hosokawa H, Hasegawa A, Motohashi S, Iwama A, Nakayama T. 2008. Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. 205(5):1109-1120.
Wimmer-Kleikamp SH, Nievergall E, Gegenbauer K, Adikari S, Mansour M, Yeadon T, Boyd AW, Patani NR, Lackmann M. 2008. Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells. 112(3):721-732.
Wierzbicki A, Gil M, Ciesielski M, Fenstermaker RA, Kaneko Y, Rokita H, Lau JT, Kozbor D. 2008. Immunization with a Mimotope of GD2 Ganglioside Induces CD8+T Cells That Recognize Cell Adhesion Molecules on Tumor Cells. J Immunol. 181(9):6644-6653.
Wei D, Kanai M, Jia Z, Le X, Xie K. 2008. Krüppel-like Factor 4 Induces p27Kip1 Expression in and Suppresses the Growth and Metastasis of Human Pancreatic Cancer Cells. Cancer Res. 68(12):4631-4639.
Vasilcanu R, Vasilcanu D, Rosengren L, Natalishvili N, Sehat B, Yin S, Girnita A, Axelson M, Girnita L, Larsson O. 2008. Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and ?-arrestin1. Oncogene. 27(11):1629-1638.
Varghese B, Barriere H, Carbone CJ, Banerjee A, Swaminathan G, Plotnikov A, Xu P, Peng J, Goffin V, Lukacs GL, et al. 2008. Polyubiquitination of Prolactin Receptor Stimulates Its Internalization, Postinternalization Sorting, and Degradation via the Lysosomal Pathway. MCB. 28(17):5275-5287.
Ueffing N, Schuster M, Keil E, Schulze-Osthoff K, Schmitz I. 2008. Up-regulation of c-FLIPshort by NFAT contributes to apoptosis resistance of short-term activated T cells. 112(3):690-698.
Tsai RK, Discher DE. 2008. Inhibition of ?self? engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. 180(5):989-1003.
Sun Y, Fang Y, Yoon M, Zhang C, Roccio M, Zwartkruis FJ, Armstrong M, Brown HA, Chen J. 2008. Phospholipase D1 is an effector of Rheb in the mTOR pathway. Proceedings of the National Academy of Sciences. 105(24):8286-8291.
Snider JL, Allison C, Bellaire BH, Ferrero RL, Cardelli JA. 2008. The ?1 Integrin Activates JNK Independent of CagA, and JNK Activation Is Required for Helicobacter pylori CagA+-induced Motility of Gastric Cancer Cells. Journal of Biological Chemistry. 283(20):13952-13963.
Sierra JR, Corso S, Caione L, Cepero V, Conrotto P, Cignetti A, Piacibello W, Kumanogoh A, Kikutani H, Comoglio PM, et al. 2008. Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages. 205(7):1673-1685.
Shimamura T, Li D, Ji H, Haringsma HJ, Liniker E, Borgman CL, Lowell AM, Minami Y, McNamara K, Perera SA, et al. 2008. Hsp90 Inhibition Suppresses Mutant EGFR-T790M Signaling and Overcomes Kinase Inhibitor Resistance. Cancer Res. 68(14):5827-5838.
Sher F, Rößler R, Brouwer N, Balasubramaniyan V, Boddeke E, Copray S. 2008. Differentiation of Neural Stem Cells into Oligodendrocytes: Involvement of the Polycomb Group Protein Ezh2. Stem Cells. 26(11):2875-2883.
Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, et al. 2008. The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes & Development. 22(19):2664-2676.
Shaikh FM, Seales EC, Clem WC, Hennessy KM, Zhuo Y, Bellis SL. 2008. Tumor cell migration and invasion are regulated by expression of variant integrin glycoforms. Experimental Cell Research. 314(16):2941-2950.
Sen N, Hara MR, Kornberg MD, Cascio MB, Bae B, Shahani N, Thomas B, Dawson TM, Dawson VL, Snyder SH, et al. 2008. Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nat Cell Biol. 10(7):866-873.
Roukens MG, Alloul-Ramdhani M, Moghadasi S, Op den Brouw M, Baker DA. 2008. Downregulation of Vertebrate Tel (ETV6) and Drosophila Yan Is Facilitated by an Evolutionarily Conserved Mechanism of F-Box-Mediated Ubiquitination. MCB. 28(13):4394-4406.
Rouget R, Auclair Y, Loignon M, Affar EB, Drobetsky EA. 2008. A Sensitive Flow Cytometry-based Nucleotide Excision Repair Assay Unexpectedly Reveals That Mitogen-activated Protein Kinase Signaling Does Not Regulate the Removal of UV-induced DNA Damage in Human Cells. Journal of Biological Chemistry. 283(9):5533-5541.
Pfister S, Janzarik WG, Remke M, Ernst A, Werft W, Becker N, Toedt G, Wittmann A, Kratz C, Olbrich H, et al. 2008. BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas. J. Clin. Invest.. 118(5):1739-1749.
Park JT, Shih I, Wang T. 2008. Identification of Pbx1, a Potential Oncogene, as a Notch3 Target Gene in Ovarian Cancer. Cancer Res. 68(21):8852-8860.
Park Y, Yoon SK, Yoon J. 2008. TRIP12 functions as an E3 ubiquitin ligase of APP-BP1. Biochemical and Biophysical Research Communications. 374(2):294-298.
Nogueira E, Fidalgo M, Molnar A, Kyriakis J, Force T, Zalvide J, Pombo CM. 2008. SOK1 Translocates from the Golgi to the Nucleus upon Chemical Anoxia and Induces Apoptotic Cell Death. Journal of Biological Chemistry. 283(23):16248-16258.
Mortensen OV, Larsen MB, Prasad BM, Amara SG. 2008. Genetic Complementation Screen Identifies a Mitogen-activated Protein Kinase Phosphatase, MKP3, as a Regulator of Dopamine Transporter Trafficking. MBoC. 19(7):2818-2829.
Martin-Granados C, Philp A, Oxenham SK, Prescott AR, Cohen PT. 2008. Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases. The International Journal of Biochemistry & Cell Biology. 40(10):2315-2332.
Magenta A, Fasanaro P, Romani S, Di Stefano V, Capogrossi MC, Martelli F. 2008. Protein Phosphatase 2A Subunit PR70 Interacts with pRb and Mediates Its Dephosphorylation. MCB. 28(2):873-882.
Lukashchuk V, McFarlane S, Everett RD, Preston CM. 2008. Human Cytomegalovirus Protein pp71 Displaces the Chromatin-Associated Factor ATRX from Nuclear Domain 10 at Early Stages of Infection. JVI. 82(24):12543-12554.
Loo Y, Fornek J, Crochet N, Bajwa G, Perwitasari O, Martinez-Sobrido L, Akira S, Gill MA, Garci?a-Sastre A, Katze MG, et al. 2008. Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity. JVI. 82(1):335-345.
Liau S, Whang E. 2008. HMGA1 Is a Molecular Determinant of Chemoresistance to Gemcitabine in Pancreatic Adenocarcinoma. Clin Cancer Res. 14(5):1470-1477.
Lepagnol-Bestel A, Maussion G, Boda B, Cardona A, Iwayama Y, Delezoide A, Moalic J, Muller D, Dean B, Yoshikawa T, et al. 2008. SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects. Mol Psychiatry. 13(4):385-397.
Lamar JM, Pumiglia KM, DiPersio CM. 2008. An Immortalization-Dependent Switch in Integrin Function Up-regulates MMP-9 to Enhance Tumor Cell Invasion. Cancer Res. 68(18):7371-7379.
Koh SM, Chandrasekara K, Abbondandolo CJ, Coll TJ, Rutzen AR. 2008. VIP and VIP Gene Silencing Modulation of Differentiation Marker N-Cadherin and Cell Shape of Corneal Endothelium in Human Corneas Ex Vivo. Invest. Ophthalmol. Vis. Sci.. 49(8):3491.
Kim J, Kim JE, Liu H, Cao W, Chen J. 2008. Regulation of Interleukin-6-induced Hepatic Insulin Resistance by Mammalian Target of Rapamycin through the STAT3-SOCS3 Pathway. Journal of Biological Chemistry. 283(2):708-715.
Kappes F, Fahrer J, Khodadoust MS, Tabbert A, Strasser C, Mor-Vaknin N, Moreno-Villanueva M, Bu?rkle A, Markovitz DM, Ferrando-May E. 2008. DEK Is a Poly(ADP-Ribose) Acceptor in Apoptosis and Mediates Resistance to Genotoxic Stress. MCB. 28(10):3245-3257.
Jong A, Wu C, Prasadarao NV, Kwon-Chung KJ, Chang YC, Ouyang Y, Shackleford GM, Huang S. 2008. Invasion ofCryptococcus neoformansinto human brain microvascular endothelial cells requires protein kinase C-? activation. 10(9):1854-1865.
Jiang CC, Lucas K, Avery-Kiejda KA, Wade M, deBock CE, Thorne RF, Allen J, Hersey P, Zhang XD. 2008. Up-regulation of Mcl-1 Is Critical for Survival of Human Melanoma Cells upon Endoplasmic Reticulum Stress. Cancer Res. 68(16):6708-6717.
Jiang CC, Lucas K, Avery-Kiejda KA, Wade M, deBock CE, Thorne RF, Allen J, Hersey P, Zhang XD. 2008. Up-regulation of Mcl-1 Is Critical for Survival of Human Melanoma Cells upon Endoplasmic Reticulum Stress. Cancer Res. 68(16):6708-6717.
Ji Z, Mei FC, Miller AL, Thompson E, Cheng X. 2008. Protein Kinase A (PKA) Isoform RII? Mediates the Synergistic Killing Effect of cAMP and Glucocorticoid in Acute Lymphoblastic Leukemia Cells. Journal of Biological Chemistry. 283(32):21920-21925.
Ji W, Yang L, Yu L, Yuan J, Hu D, Zhang W, Yang J, Pang Y, Li W, Lu J, et al. 2008. Epigenetic silencing of O6 -methylguanine DNA methyltransferase gene in NiS-transformed cells. 29(6):1267-1275.
Janoueix-Lerosey I, Lequin D, Brugières L, Ribeiro A, de Pontual L, Combaret V, Raynal V, Puisieux A, Schleiermacher G, Pierron G, et al. 2008. Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. Nature. 455(7215):967-970.
Ishikawa H, Barber GN. 2008. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature. 455(7213):674-678.
Hoskins EE, Gunawardena RW, Habash KB, Wise-Draper TM, Jansen M, Knudsen ES, Wells SI. 2008. Coordinate regulation of Fanconi anemia gene expression occurs through the Rb/E2F pathway. Oncogene. 27(35):4798-4808.
Hähnel PS, Thaler S, Antunes E, Huber C, Theobald M, Schuler M. 2008. Targeting AKT Signaling Sensitizes Cancer to Cellular Immunotherapy. Cancer Res. 68(10):3899-3906.
Gu J, Lim SO, Park YM, Jung G. 2008. A novel splice variant of occludin deleted in exon?9 and its role in cell apoptosis and invasion. 275(12):3145-3156.
Goncalves S, Paupe V, Dassa EP, Rustin P. 2008. Deferiprone targets aconitase: Implication for Friedreich's ataxia treatment. BMC Neurol. 8(1):
Gendron TF, McCartney S, Causevic E, Ko L, Yen S. 2008. Ethanol enhances tau accumulation in neuroblastoma cells that inducibly express tau. Neuroscience Letters. 443(2):67-71.
Fung C, Lock R, Gao S, Salas E, Debnath J. 2008. Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival. MBoC. 19(3):797-806.
Fukazawa T, Matsuoka J, Naomoto Y, Maeda Y, Durbin ML, Tanaka N. 2008. Malignant Pleural Mesothelioma?Targeted CREBBP/EP300 Inhibitory Protein 1 Promoter System for Gene Therapy and Virotherapy. Cancer Res. 68(17):7120-7129.
Frederick LA, Matthews JA, Jamieson L, Justilien V, Thompson EA, Radisky DC, Fields AP. 2008. Matrix metalloproteinase-10 is a critical effector of protein kinase C?-Par6?-mediated lung cancer. Oncogene. 27(35):4841-4853.
Fattah FJ, Lichter NF, Fattah KR, Oh S, Hendrickson EA. 2008. Ku70, an essential gene, modulates the frequency of rAAV-mediated gene targeting in human somatic cells. Proceedings of the National Academy of Sciences. 105(25):8703-8708.
Escriva? M, Peiro? S, Herranz N, Villagrasa P, Dave N, Montserrat-Senti?s B, Murray SA, Franci? C, Gridley T, Virtanen I, et al. 2008. Repression of PTEN Phosphatase by Snail1 Transcriptional Factor during Gamma Radiation-Induced Apoptosis. MCB. 28(5):1528-1540.
Eguchi J, Yan Q, Schones DE, Kamal M, Hsu C, Zhang MQ, Crawford GE, Rosen ED. 2008. Interferon Regulatory Factors Are Transcriptional Regulators of Adipogenesis. Cell Metabolism. 7(1):86-94.
Duan Z, Weinstein EJ, Ji D, Ames RY, Choy E, Mankin H, Hornicek FJ. 2008. Lentiviral short hairpin RNA screen of genes associated with multidrug resistance identifies PRP-4 as a new regulator of chemoresistance in human ovarian cancer. Mol Cancer Ther. 7(8):2377-2385.
Clarke E, Rahman N, Page N, Rolph MS, Stewart GJ, Jones GJ. 2008. Functional characterization of the atopy-associated gene PHF11. Journal of Allergy and Clinical Immunology. 121(5):1148-1154.e3.
Cheng GZ, Zhang W, Sun M, Wang Q, Coppola D, Mansour M, Xu L, Costanzo C, Cheng JQ, Wang L. 2008. Twist Is Transcriptionally Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function. Journal of Biological Chemistry. 283(21):14665-14673.
Chang T, Yu D, Lee Y, Wentzel EA, Arking DE, West KM, Dang CV, Thomas-Tikhonenko A, Mendell JT. 2008. Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet. 40(1):43-50.
Caramel J, Medjkane S, Quignon F, Delattre O. 2008. The requirement for SNF5/INI1 in adipocyte differentiation highlights new features of malignant rhabdoid tumors. Oncogene. 27(14):2035-2044.
Caramel J, Quignon F, Delattre O. 2008. RhoA-Dependent Regulation of Cell Migration by the Tumor Suppressor hSNF5/INI1. Cancer Res. 68(15):6154-6161.
Callejas-Valera JL, Guinea-Viniegra J, Ramírez-Castillejo C, Recio JA, Galan-Moya E, Martinez N, Rojas JM, Cajal SRy, Sánchez-Prieto R. 2008. E1a Gene Expression Blocks the ERK1/2 Signaling Pathway by Promoting Nuclear Localization and MKP Up-regulation. Journal of Biological Chemistry. 283(19):13450-13458.
Borrelli S, Candi E, Alotto D, Castagnoli C, Melino G, Viganò MA, Mantovani R. 2009. p63 regulates the caspase-8-FLIP apoptotic pathway in epidermis. Cell Death Differ. 16(2):253-263.
Bernard-Pierrot I, Gruel N, Stransky N, Vincent-Salomon A, Reyal F, Raynal V, Vallot C, Pierron G, Radvanyi F, Delattre O. 2008. Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer. Cancer Res. 68(17):7165-7175.
Bao S, Wu Q, Li Z, Sathornsumetee S, Wang H, McLendon RE, Hjelmeland AB, Rich JN. 2008. Targeting Cancer Stem Cells through L1CAM Suppresses Glioma Growth. Cancer Res. 68(15):6043-6048.
Azran-Shaish I, Tabakin-Fix Y, Huleihel M, Bakhanashvili M, Aboud M. 2008. HTLV-1 Tax-induced NF-?B activation is synergistically enhanced by 12-O-tetradecanoylphorbol-13-acetate: mechanism and implications for Tax oncogenicity. J Mol Med. 86(7):799-814.
Al-Hakim A, Zagorska A, Chapman L, Deak M, Peggie M, Alessi D. 2008. Control of AMPK-related kinases by USP9X and atypical Lys29/Lys33-linked polyubiquitin chains. 411(2):249-260.
Ahmed AU, Schmidt RL, Park CH, Reed NR, Hesse SE, Thomas CF, Molina JR, Deschamps C, Yang P, Aubry MC, et al. 2008. Effect of Disrupting Seven-in-Absentia Homolog 2 Function on Lung Cancer Cell Growth. 100(22):1606-1629.
Yang L, Sun M, Sun X, Cheng GZ, Nicosia SV, Cheng JQ. 2007. Akt Attenuation of the Serine Protease Activity of HtrA2/Omi through Phosphorylation of Serine 212. Journal of Biological Chemistry. 282(15):10981-10987.
Villa-Moruzzi E. 2007. Targeting of FAK Ser910 by ERK5 and PP1? in non-stimulated and phorbol ester-stimulated cells. 408(1):7-18.
Haar EV, Lee S, Bandhakavi S, Griffin TJ, Kim D. 2007. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol. 9(3):316-323.
Scholl C, Bansal D, Döhner K, Eiwen K, Huntly BJ, Lee BH, Rücker FG, Schlenk RF, Bullinger L, Döhner H, et al. 2007. The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis. J. Clin. Invest.. 117(4):1037-1048.
Schmidt RL, Park CH, Ahmed AU, Gundelach JH, Reed NR, Cheng S, Knudsen BE, Tang AH. 2007. Inhibition of RAS-Mediated Transformation and Tumorigenesis by Targeting the Downstream E3 Ubiquitin Ligase Seven in Absentia Homologue. Cancer Research. 67(24):11798-11810.
Sánchez-Sánchez F, Martínez-Redondo F, Aroca-Aguilar JD, Coca-Prados M, Escribano J. 2007. Characterization of the Intracellular Proteolytic Cleavage of Myocilin and Identification of Calpain II as a Myocilin-processing Protease. Journal of Biological Chemistry. 282(38):27810-27824.
Rizzi M, Tschan MP, Britschgi C, Britschgi A, Hügli B, Grob TJ, Leupin N, Mueller BU, Simon H, Ziemiecki A, et al. 2007. The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells. Journal of Leukocyte Biology. 81(6):1599-1608.
Ravitz MJ, Chen L, Lynch M, Schmidt EV. 2007. c-myc Repression of TSC2 Contributes to Control of Translation Initiation and Myc-Induced Transformation. Cancer Res. 67(23):11209-11217.
Qian Y, Schmidt RJ, Zhang Y, Chu S, Lin A, Wang H, Wang X, Beyer TP, Bensch WR, Li W, et al. 2007. Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. Journal of Lipid Research. 48(7):1488-1498.
Pottier N, Cheok MH, Yang W, Assem M, Tracey L, Obenauer JC, Panetta JC, Relling MV, Evans WE. Expression of SMARCB1 modulates steroid sensitivity in human lymphoblastoid cells: identification of a promoter snp that alters PARP1 binding and SMARCB1 expression. Human Molecular Genetics. 16(19):2261-2271.
Patel JH, McMahon SB. 2007. BCL2 Is a Downstream Effector of MIZ-1 Essential for Blocking c-MYC-induced Apoptosis. Journal of Biological Chemistry. 282(1):5-13.
Pallerla SR, Pan Y, Zhang X, Esko JD, Grobe K. 2007. Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development. Dev. Dyn.. 236(2):556-563.
Neilson LM, Zhu J, Xie J, Malabarba MG, Sakamoto K, Wagner K, Kirken RA, Rui H. 2007. Coactivation of Janus Tyrosine Kinase (Jak)1 Positively Modulates Prolactin-Jak2 Signaling in Breast Cancer: Recruitment of ERK and Signal Transducer and Activator of Transcription (Stat)3 and Enhancement of Akt and Stat5a/b Pathways. 21(9):2218-2232.
Liau S, Jazag A, Ito K, Whang EE. 2007. Overexpression of HMGA1 promotes anoikis resistance and constitutive Akt activation in pancreatic adenocarcinoma cells. Br J Cancer. 96(6):993-1000.
Lee NO, Son YJ, Kim JG, Ha CM, Yun CH, Lim HL, Park JW, D?Elia AV, Damante G, Lee BJ. 2007. TTF-1 regulates growth hormone and prolactin transcription in the anterior pituitary gland. Biochemical and Biophysical Research Communications. 362(1):193-199.
Lee H, Kim D, Dan HC, Wu EL, Gritsko TM, Cao C, Nicosia SV, Golemis EA, Liu W, Coppola D, et al. 2007. Identification and Characterization of Putative Tumor Suppressor NGB, a GTP-Binding Protein That Interacts with the Neurofibromatosis 2 Protein. MCB. 27(6):2103-2119.
Kim J, Lee C, Bonifant CL, Ressom H, Waldman T. 2007. Activation of p53-Dependent Growth Suppression in Human Cells by Mutations in PTEN or PIK3CA. MCB. 27(2):662-677.
Kanematsu A, Ramachandran A, Adam RM. 2007. GATA-6 mediates human bladder smooth muscle differentiation: involvement of a novel enhancer element in regulating ?-smooth muscle actin gene expression. American Journal of Physiology-Cell Physiology. 293(3):C1093-C1102.
Hirai Y, Nelson CM, Yamazaki K, Takebe K, Przybylo J, Madden B, Radisky DC. 2007. Non-classical export of epimorphin and its adhesion to ?v-integrin in regulation of epithelial morphogenesis. 120(12):2032-2043.
Guicciardi ME, Bronk SF, Werneburg NW, Gores GJ. 2007. cFLIPL prevents TRAIL-induced apoptosis of hepatocellular carcinoma cells by inhibiting the lysosomal pathway of apoptosis. American Journal of Physiology-Gastrointestinal and Liver Physiology. 292(5):G1337-G1346.
Grimm D, Kay MA. 2007. Therapeutic application of RNAi: is mRNA targeting finally ready for prime time?. J. Clin. Invest.. 117(12):3633-3641.
Gatot J, Gioia R, Chau T, Patrascu F, Warnier M, Close P, Chapelle J, Muraille E, Brown K, Siebenlist U, et al. 2007. Lipopolysaccharide-mediated Interferon Regulatory Factor Activation Involves TBK1-IKK?-dependent Lys63-linked Polyubiquitination and Phosphorylation of TANK/I-TRAF. Journal of Biological Chemistry. 282(43):31131-31146.
Fröhling S, Scholl C, Levine RL, Loriaux M, Boggon TJ, Bernard OA, Berger R, Döhner H, Döhner K, Ebert BL, et al. 2007. Identification of Driver and Passenger Mutations of FLT3 by High-Throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles. Cancer Cell. 12(6):501-513.
Fang H, Strom SC, Ellis E, Duanmu Z, Fu J, Duniec-Dmuchowski Z, Falany CN, Falany JL, Kocarek TA, Runge-Morris M. 2007. Positive and Negative Regulation of Human Hepatic Hydroxysteroid Sulfotransferase (SULT2A1) Gene Transcription by Rifampicin: Roles of Hepatocyte Nuclear Factor 4? and Pregnane X Receptor. J Pharmacol Exp Ther. 323(2):586-598.
Dai C, Whitesell L, Rogers AB, Lindquist S. 2007. Heat Shock Factor 1 Is a Powerful Multifaceted Modifier of Carcinogenesis. Cell. 130(6):1005-1018.
Cortina C, Palomo-Ponce S, Iglesias M, Fernández-Masip JL, Vivancos A, Whissell G, Humà M, Peiró N, Gallego L, Jonkheer S, et al. 2007. EphB?ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. Nat Genet. 39(11):1376-1383.
Chiappetta G, De Marco C, Quintiero A, Califano D, Gherardi S, Malanga D, Scrima M, Montero-Conde C, Cito L, Monaco M, et al. 2007. Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer. Endocr Relat Cancer. 14(2):405-420.
Cheng A, Shin-ya K, Wan R, Tang S, Miura T, Tang H, Khatri R, Gleichman M, Ouyang X, Liu D, et al. 2007. Telomere Protection Mechanisms Change during Neurogenesis and Neuronal Maturation: Newly Generated Neurons Are Hypersensitive to Telomere and DNA Damage. Journal of Neuroscience. 27(14):3722-3733.
Carrithers MD, Dib-Hajj S, Carrithers LM, Tokmoulina G, Pypaert M, Jonas EA, Waxman SG. 2007. Expression of the Voltage-Gated Sodium Channel NaV1.5 in the Macrophage Late Endosome Regulates Endosomal Acidification. J Immunol. 178(12):7822-7832.
Bush CR, Havens JM, Necela BM, Su W, Chen L, Yanagisawa M, Anastasiadis PZ, Guerra R, Luxon BA, Thompson EA. 2007. Functional Genomic Analysis Reveals Cross-talk between Peroxisome Proliferator-activated Receptor ? and Calcium Signaling in Human Colorectal Cancer Cells. Journal of Biological Chemistry. 282(32):23387-23401.
Binné UK, Classon MK, Dick FA, Wei W, Rape M, Kaelin WG, Näär AM, Dyson NJ. 2007. Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. Nat Cell Biol. 9(2):225-232.
Bar EE, Chaudhry A, Lin A, Fan X, Schreck K, Matsui W, Piccirillo S, Vescovi AL, DiMeco F, Olivi A, et al. 2007. Cyclopamine-Mediated Hedgehog Pathway Inhibition Depletes Stem-Like Cancer Cells in Glioblastoma. Stem Cells. 25(10):2524-2533.
Yousefi S, Perozzo R, Schmid I, Ziemiecki A, Schaffner T, Scapozza L, Brunner T, Simon H. 2006. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol. 8(10):1124-1132.
Takeda S. 2006. Proteolysis of MLL family proteins is essential for Taspase1-orchestrated cell cycle progression. Genes & Development. 20(17):2397-2409.
Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS, McMahon SB. 2006. Acetylation of the p53 DNA-Binding Domain Regulates Apoptosis Induction. Molecular Cell. 24(6):841-851.
Smoak K, Cidlowski JA. 2006. Glucocorticoids Regulate Tristetraprolin Synthesis and Posttranscriptionally Regulate Tumor Necrosis Factor Alpha Inflammatory Signaling. MCB. 26(23):9126-9135.
Root DE, Hacohen N, Hahn WC, Lander ES, Sabatini DM. 2006. Genome-scale loss-of-function screening with a lentiviral RNAi library. Nat Methods. 3(9):715-719.
LIAU S, ASHLEY S, WHANG E. 2006. Lentivirus-Mediated RNA Interference of HMGA1 Promotes Chemosensitivity to Gemcitabine in Pancreatic Adenocarcinoma. Journal of Gastrointestinal Surgery. 10(9):1254-1263.
Liau S, Jazag A, Whang EE. 2006. HMGA1 Is a Determinant of Cellular Invasiveness and In vivo Metastatic Potential in Pancreatic Adenocarcinoma. Cancer Res. 66(24):11613-11622.
Fu Z, Larson KA, Chitta RK, Parker SA, Turk BE, Lawrence MW, Kaldis P, Galaktionov K, Cohn SM, Shabanowitz J, et al. 2006. Identification of Yin-Yang Regulators and a Phosphorylation Consensus for Male Germ Cell-Associated Kinase (MAK)-Related Kinase. MCB. 26(22):8639-8654.
Everett RD, Rechter S, Papior P, Tavalai N, Stamminger T, Orr A. 2006. PML Contributes to a Cellular Mechanism of Repression of Herpes Simplex Virus Type 1 Infection That Is Inactivated by ICP0. JVI. 80(16):7995-8005.
DARCANGELO D, AMBROSINO V, GIANNUZZO M, GAETANO C, CAPOGROSSI M. 2006. Axl receptor activation mediates laminar shear stress anti-apoptotic effects in human endothelial cells. Cardiovascular Research. 71(4):754-763.
Ito M, Kawano K, Miyagishi M, Taira K. 2005. Genome-wide application of RNAi to the discovery of potential drug targets. 579(26):5988-5995.
Tang F, Meng G, Yang H, Li C, Shi Y, Ding M, Shang K, Zhang B, Xue Y. 2004. Stable Suppression of Gene Expression in Murine Embryonic Stem Cells by RNAi Directed from DNA Vector-Based Short Hairpin RNA. Stem Cells. 22(1):93-99.
STEWART SA. 2003. Lentivirus-delivered stable gene silencing by RNAi in primary cells. 9(4):493-501.
Bridge AJ, Pebernard S, Ducraux A, Nicoulaz A, Iggo R. 2003. Induction of an interferon response by RNAi vectors in mammalian cells. Nat Genet. 34(3):263-264.
Boden D. 2003. Promoter choice affects the potency of HIV-1 specific RNA interference. Nucleic Acids Research. 31(17):5033-5038.


Ali N, Karlsson C, Aspling M, Hu G, Hacohen N, Scadden DT, Larsson J. 2009. Forward RNAi screens in primary human hematopoietic stem/progenitor cells. 113(16):3690-3695.
Ebert BL, Pretz J, Bosco J, Chang CY, Tamayo P, Galili N, Raza A, Root DE, Attar E, Ellis SR, et al. 2008. Identification of RPS14 as a 5q- syndrome gene by RNA interference screen. Nature. 451(7176):335-339.
Firestein R, Bass AJ, Kim SY, Dunn IF, Silver SJ, Guney I, Freed E, Ligon AH, Vena N, Ogino S, et al. 2008. CDK8 is a colorectal cancer oncogene that regulates ?-catenin activity. Nature. 455(7212):547-551.
Fröhling S, Scholl C, Levine RL, Loriaux M, Boggon TJ, Bernard OA, Berger R, Döhner H, Döhner K, Ebert BL, et al. 2007. Identification of Driver and Passenger Mutations of FLT3 by High-Throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles. Cancer Cell. 12(6):501-513.
Jones DC. 2006. Regulation of Adult Bone Mass by the Zinc Finger Adapter Protein Schnurri-3. Science. 312(5777):1223-1227.
Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A. 2008. Regulation of CD45 Alternative Splicing by Heterogeneous Ribonucleoprotein, hnRNPLL. Science. 321(5889):686-691.
Pagliarini DJ, Calvo SE, Chang B, Sheth SA, Vafai SB, Ong S, Walford GA, Sugiana C, Boneh A, Chen WK, et al. 2008. A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology. Cell. 134(1):112-123.
Scholl C, Bansal D, Döhner K, Eiwen K, Huntly BJ, Lee BH, Rücker FG, Schlenk RF, Bullinger L, Döhner H, et al. 2007. The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis. J. Clin. Invest.. 117(4):1037-1048.
Seok Yang W, Stockwell BR. 2008. Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest. Genome Biol. 9(6):R92.
Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, et al. 2007. Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene. Cell. 129(6):1065-1079.
Fotiadou PP, Takahashi C, Rajabi HN, Ewen ME. 2007. Wild-Type NRas and KRas Perform Distinct Functions during Transformation. MCB. 27(19):6742-6755.
Kim M, Gans JD, Nogueira C, Wang A, Paik J, Feng B, Brennan C, Hahn WC, Cordon-Cardo C, Wagner SN, et al. 2006. Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene. Cell. 125(7):1269-1281.
Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, et al. 2006. A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen. Cell. 124(6):1283-1298.
Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM. 2007. PRAS40 Is an Insulin-Regulated Inhibitor of the mTORC1 Protein Kinase. Molecular Cell. 25(6):903-915.

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